| UniProt Protein Function: | PFKFB2: a bifunctional heterodimeric enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. Regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 3.1.3.46; Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; Kinase, other; Phosphatase (non-protein); Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q31 Cellular Component: cytosol Molecular Function:6-phosphofructo-2-kinase activity; protein binding; protein kinase binding Biological Process: glycolysis |
| NCBI Summary: | The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60825 |
| NCBI GenInfo Identifier: | 12643333 |
| NCBI Gene ID: | 5208 |
| NCBI Accession: | O60825.2 |
| UniProt Secondary Accession: | O60825,O60824, Q5VVQ3, Q5VVQ4, Q9H3P1, |
| UniProt Related Accession: | O60825 |
| Molecular Weight: | 54,406 Da |
| NCBI Full Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
| NCBI Synonym Full Names: | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 |
| NCBI Official Symbol: | PFKFB2 |
| NCBI Official Synonym Symbols: | PFK-2/FBPase-2 |
| NCBI Protein Information: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
| UniProt Protein Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
| UniProt Synonym Protein Names: | 6PF-2-K/Fru-2,6-P2ase heart-type isozymeIncluding the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105)Fructose-2,6-bisphosphatase (EC:3.1.3.46) |
| Protein Family: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase |
| UniProt Gene Name: | PFKFB2 |
| UniProt Entry Name: | F262_HUMAN |
