| UniProt Protein Function: | CDC25B: a member of the MPI phosphatase family. Activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. Shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. At least four transcript variants for this gene exist. Three splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 3.1.3.48; Nuclear receptor co-regulator; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 20p13 Cellular Component: nucleoplasm; spindle pole; centrosome; cytoplasm; cytosol Molecular Function:protein binding; protein tyrosine phosphatase activity; protein kinase binding Biological Process: positive regulation of cytokinesis; mitosis; cell division; positive regulation of protein kinase activity; positive regulation of cell proliferation; mitotic cell cycle; G2/M transition of mitotic cell cycle; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; oocyte maturation; female meiosis I |
| NCBI Summary: | CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30305 |
| NCBI GenInfo Identifier: | 4757950 |
| NCBI Gene ID: | 994 |
| NCBI Accession: | NP_004349.1 |
| UniProt Secondary Accession: | P30305,O43551, Q13971, Q5JX77, Q6RSS1, Q9BRA6, D3DVY1 D3DVY2, D3DVY3, D3DVY4, |
| UniProt Related Accession: | P30305 |
| Molecular Weight: | 64,987 Da |
| NCBI Full Name: | M-phase inducer phosphatase 2 isoform 2 |
| NCBI Synonym Full Names: | cell division cycle 25B |
| NCBI Official Symbol: | CDC25B |
| NCBI Protein Information: | M-phase inducer phosphatase 2; dual specificity phosphatase Cdc25B |
| UniProt Protein Name: | M-phase inducer phosphatase 2 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase Cdc25B |
| UniProt Gene Name: | CDC25B |
| UniProt Entry Name: | MPIP2_HUMAN |
