PFKFB2 Antibody (PACO21696)
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주문- SKU:
- PACO21696
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PFKFB2 Antibody (PACO21696) |
Antibody SKU: | PACO21696 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from N-terminal of human PFKFB2. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from Jurkat cells, using PFKFB2 antibody. |
Background: | Synthesis and degradation of fructose 2,6-bisphosphate. Soejima H., Genomics 74:115-120(2001). |
Synonyms: | 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2; 6-biphosphatase 2; 6PF-2-K/Fru-2; 6-P2ase heart-type isozyme |
UniProt Protein Function: | PFKFB2: a bifunctional heterodimeric enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. Regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. Two splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:EC 3.1.3.46; Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; Kinase, other; Phosphatase (non-protein); Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q31 Cellular Component: cytosol Molecular Function:6-phosphofructo-2-kinase activity; protein binding; protein kinase binding Biological Process: glycolysis |
NCBI Summary: | The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60825 |
NCBI GenInfo Identifier: | 12643333 |
NCBI Gene ID: | 5208 |
NCBI Accession: | O60825.2 |
UniProt Secondary Accession: | O60825,O60824, Q5VVQ3, Q5VVQ4, Q9H3P1, |
UniProt Related Accession: | O60825 |
Molecular Weight: | 54,406 Da |
NCBI Full Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
NCBI Synonym Full Names: | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 |
NCBI Official Symbol: | PFKFB2 |
NCBI Official Synonym Symbols: | PFK-2/FBPase-2 |
NCBI Protein Information: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
UniProt Protein Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
UniProt Synonym Protein Names: | 6PF-2-K/Fru-2,6-P2ase heart-type isozymeIncluding the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105)Fructose-2,6-bisphosphatase (EC:3.1.3.46) |
Protein Family: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase |
UniProt Gene Name: | PFKFB2 |
UniProt Entry Name: | F262_HUMAN |
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