PEG10 Antibody (PACO37226)
- SKU:
- PACO37226
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | PEG10 Antibody (PACO37226) |
| Antibody SKU: | PACO37226 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Retrotransposon-derived protein PEG10 protein (1-325AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO37226 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO37226 at dilution of 1:100. |
| Background: | Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-β signaling by interacting with the TGF-β receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation By similarity. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter |
| Synonyms: | Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein), PEG10, EDR KIAA1051 MAR2 MART2 MEF3L1 RGAG3 |
| UniProt Protein Function: | PEG10: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter. Up-regulated by MYC and dihydrotestosteron (DHT). Interacts with ALK1, SIAH1 and SIAH2. 2 isoforms of the human protein are produced by ribosomal frameshifting. |
| UniProt Protein Details: | Protein type:RNA-binding; Cell cycle regulation; Apoptosis; Cell development/differentiation Chromosomal Location of Human Ortholog: 7q21 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; DNA binding; zinc ion binding Biological Process: apoptosis; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway |
| UniProt Code: | Q86TG7 |
| NCBI GenInfo Identifier: | 172046699 |
| NCBI Gene ID: | |
| NCBI Accession: | Q86TG7.2 |
| Molecular Weight: | 55kDa |
| NCBI Full Name: | Retrotransposon-derived protein PEG10 |
| UniProt Protein Name: | Retrotransposon-derived protein PEG10 |
| UniProt Synonym Protein Names: | Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein |
| Protein Family: | Retrotransposon-derived protein |
| UniProt Gene Name: | PEG10 |
| UniProt Entry Name: | PEG10_HUMAN |
| Antibodies | ELISA Kits |
| Anti-PEG10 Antibody (CAB2787) | Human PEG10 / EDR ELISA Kit |
| PEG10 Antibody (PACO11164) | Human Retrotransposon-derived protein PEG10 (PEG10) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Human Retrotransposon-derived protein PEG10 (PEG10) ELISA Kit
Mouse Retrotransposon-derived protein PEG10 (Peg10) ELISA Kit
Human PEG10 / EDR ELISA Kit
