Pdxp Antibody (PACO53714)
- SKU:
- PACO53714
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | Pdxp Antibody (PACO53714) |
| Antibody SKU: | PACO53714 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Mouse, Rat |
| Immunogen: | Recombinant Mouse Pyridoxal phosphate phosphatase protein (1-292AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat brain tissue. All lanes: Pdxp antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa. |
| Background: | Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis (By similarity). Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. |
| Synonyms: | Pyridoxal phosphate phosphatase (PLP phosphatase) (EC 3.1.3.3) (EC 3.1.3.74) (Chronophin), Pdxp, Cin Plp Plpp |
| UniProt Protein Function: | PDXP: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. Homodimer. Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. Inhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA. Belongs to the HAD-like hydrolase superfamily.Protein type: Cofactor and Vitamin Metabolism - vitamin B6; EC 3.1.3.74; Cell cycle regulation; EC 3.1.3.3; Protein phosphatase, Ser/Thr (non-receptor)Cellular Component: lamellipodium; plasma membrane; intercellular junction; midbody; cytosol; cleavage furrow; actin cytoskeletonMolecular Function: heat shock protein binding; phosphoprotein phosphatase activityBiological Process: actin rod formation; positive regulation of actin filament depolymerization; regulation of mitosis; protein amino acid dephosphorylation; regulation of cytokinesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P60487 |
| NCBI GenInfo Identifier: | 47059486 |
| NCBI Gene ID: | 57028 |
| NCBI Accession: | NP_064667.2 |
| UniProt Secondary Accession: | P60487 |
| UniProt Related Accession: | P60487 |
| Molecular Weight: | 33.5 kDa |
| NCBI Full Name: | pyridoxal phosphate phosphatase |
| NCBI Synonym Full Names: | pyridoxal (pyridoxine, vitamin B6) phosphatase |
| NCBI Official Symbol: | Pdxp |
| NCBI Official Synonym Symbols: | PLPP; AB041662; 1600027H05Rik |
| NCBI Protein Information: | pyridoxal phosphate phosphatase; chronophin; chronophilin; PLP phosphatase; PLP-phosophatase |
| UniProt Protein Name: | Pyridoxal phosphate phosphatase |
| UniProt Synonym Protein Names: | Chronophin |
| Protein Family: | Pyridoxal phosphate phosphatase |
| UniProt Gene Name: | Pdxp |
| UniProt Entry Name: | PLPP_MOUSE |
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