| UniProt Protein Function: | PDE9A: Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily. 16 isoforms of the human protein are produced by alternative splicing.Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.35Chromosomal Location of Human Ortholog: 21q22.3Cellular Component: Golgi apparatus; endoplasmic reticulum; perinuclear region of cytoplasm; perikaryon; cytosolMolecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; protein binding; metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activityBiological Process: cGMP-mediated signaling; metabolic process; blood coagulation; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O76083 |
| NCBI GenInfo Identifier: | 4505675 |
| NCBI Gene ID: | 5152 |
| NCBI Accession: | NP_002597.1 |
| UniProt Secondary Accession: | O76083,O75490, O75491, O95225, Q53Y40, Q5QD39, Q86SF7 Q86SI6, B2RBI5, B4DFI5 |
| UniProt Related Accession: | O76083 |
| Molecular Weight: | 56,554 Da |
| NCBI Full Name: | high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a |
| NCBI Synonym Full Names: | phosphodiesterase 9A |
| NCBI Official Symbol: | PDE9A |
| NCBI Official Synonym Symbols: | HSPDE9A2 |
| NCBI Protein Information: | high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; phosphodiesterase PDE9A21; CGMP-specific 3',5'-cyclic phosphodiesterase type 9 |
| UniProt Protein Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
| UniProt Synonym Protein Names: | |
| Protein Family: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE9A |
| UniProt Entry Name: | PDE9A_HUMAN |
