PARP2 Antibody (PACO02288)

(No reviews yet) Write a Review
SKU:
PACO02288
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Application:
ELISA
Application:
WB
Antibody type:
Polyclonal
Conjugation:
Unconjugated
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:PARP2 Antibody
Antibody SKU:PACO02288
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human PARP-2.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PARP2; ADPRT2; ADPRTL2; Poly [ADP-ribose] polymerase 2; PARP-2; hPARP-2; ADP-ribosyltransferase diphtheria toxin-like 2; ARTD2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; Poly[ADP-ribose] synthase 2; pADPRT-2
UniProt Protein Function:Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768).
NCBI Summary:This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UGN5
NCBI GenInfo Identifier:110825961
NCBI Gene ID:10038
NCBI Accession:NP_005475
UniProt Secondary Accession:Q9UGN5,Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8,
UniProt Related Accession:Q9UGN5
Molecular Weight:42.5 kDa (376aa)
NCBI Full Name:poly
NCBI Synonym Full Names:poly(ADP-ribose) polymerase 2
NCBI Official Symbol:PARP2  
NCBI Official Synonym Symbols:ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2  
NCBI Protein Information:poly [ADP-ribose] polymerase 2
UniProt Protein Name:Poly [ADP-ribose] polymerase 2
UniProt Synonym Protein Names:ADP-ribosyltransferase diphtheria toxin-like 2; ARTD2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; Poly[ADP-ribose] synthase 2; pADPRT-2
Protein Family:Poly [ADP-ribose] polymerase
UniProt Gene Name:PARP2  

0 Reviews

View AllClose

Related Products