NR3C1 Antibody (PACO03985)
- SKU:
- PACO03985
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NR3C1 Antibody |
| Antibody SKU: | PACO03985 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from human GR around the non-phosphorylation site of S203. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | NR3C1; GRL; Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1 |
| UniProt Protein Function: | GR: transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Mitochondrial; DNA-binding; Transcription factor; Nuclear receptor Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: cytoplasm; cytosol; membrane; mitochondrial matrix; nucleoplasm; nucleus Molecular Function:glucocorticoid receptor activity; protein binding; protein dimerization activity; steroid binding; transcription factor activity; zinc ion binding Biological Process: adrenal gland development; chromatin modification; gene expression; glucocorticoid mediated signaling; glucocorticoid metabolic process; glucocorticoid receptor signaling pathway; maternal behavior; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; regulation of glucocorticoid biosynthetic process; regulation of gluconeogenesis; regulation of transcription, DNA-dependent; signal transduction; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent Disease: Glucocorticoid Resistance, Generalized |
| NCBI Summary: | This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] |
| UniProt Code: | P04150 |
| NCBI GenInfo Identifier: | 121069 |
| NCBI Gene ID: | 2908 |
| NCBI Accession: | P04150.1 |
| UniProt Secondary Accession: | P04150,P04151, Q53EP5, Q6N0A4, A0ZXF9, B0LPG8, D3DQF4 |
| UniProt Related Accession: | P04150 |
| Molecular Weight: | 82,904 Da |
| NCBI Full Name: | Glucocorticoid receptor |
| NCBI Synonym Full Names: | nuclear receptor subfamily 3 group C member 1 |
| NCBI Official Symbol: | NR3C1 |
| NCBI Official Synonym Symbols: | GR; GCR; GRL; GCCR; GCRST |
| NCBI Protein Information: | glucocorticoid receptor |
| UniProt Protein Name: | Glucocorticoid receptor |
| UniProt Synonym Protein Names: | Nuclear receptor subfamily 3 group C member 1 |
| Protein Family: | Glucocorticoid receptor |
| UniProt Gene Name: | NR3C1 |
| UniProt Entry Name: | GCR_HUMAN |
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