| UniProt Protein Function: | NOS1AP: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 1q23.3Cellular Component: nuclear membrane; sarcoplasmic reticulum membrane; mitochondrion; perinuclear region of cytoplasm; T-tubule; caveola; Z disc; cytosol; nucleus; sarcolemmaMolecular Function: nitric-oxide synthase bindingBiological Process: regulation of apoptosis; regulation of nitric oxide biosynthetic process; positive regulation of nitric oxide biosynthetic process; chemical signal regulation of heart rate; positive regulation of nitric-oxide synthase activity; regulation of nitric-oxide synthase activityDisease: Qt Interval, Variation In |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009] |
| UniProt Code: | O75052 |
| NCBI GenInfo Identifier: | 205277334 |
| NCBI Gene ID: | 9722 |
| NCBI Accession: | NP_001119532.2 |
| UniProt Secondary Accession: | O75052,O43564, Q3T551, Q5VU95, B7ZLF5 |
| UniProt Related Accession: | O75052 |
| Molecular Weight: | 55,569 Da |
| NCBI Full Name: | carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 2 |
| NCBI Synonym Full Names: | nitric oxide synthase 1 (neuronal) adaptor protein |
| NCBI Official Symbol: | NOS1AP |
| NCBI Official Synonym Symbols: | CAPON; 6330408P19Rik |
| NCBI Protein Information: | carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; nitric oxide synthase 1 adaptor protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON); ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain |
| UniProt Protein Name: | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein |
| UniProt Synonym Protein Names: | C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Nitric oxide synthase 1 adaptor protein |
| Protein Family: | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein |
| UniProt Gene Name: | NOS1AP |
| UniProt Entry Name: | CAPON_HUMAN |
