| UniProt Protein Function: | NALP4: May be involved in inflammation. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 19q13.43Cellular Component: cytosolBiological Process: regulation of interferon type I production |
| UniProt Protein Details: | |
| NCBI Summary: | NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96MN2 |
| NCBI GenInfo Identifier: | 148887404 |
| NCBI Gene ID: | 147945 |
| NCBI Accession: | Q96MN2.3 |
| UniProt Secondary Accession: | Q96MN2,Q86W87, Q96AY6 |
| UniProt Related Accession: | Q96MN2 |
| Molecular Weight: | 103,968 Da |
| NCBI Full Name: | NACHT, LRR and PYD domains-containing protein 4 |
| NCBI Synonym Full Names: | NLR family pyrin domain containing 4 |
| NCBI Official Symbol: | NLRP4 |
| NCBI Official Synonym Symbols: | CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5 |
| NCBI Protein Information: | NACHT, LRR and PYD domains-containing protein 4 |
| UniProt Protein Name: | NACHT, LRR and PYD domains-containing protein 4 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 58; CT58; PAAD and NACHT-containing protein 2; PAN2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; PYPAF4; Ribonuclease inhibitor 2 |
| Protein Family: | NACHT, LRR and PYD domains-containing protein |
| UniProt Gene Name: | NLRP4 |
| UniProt Entry Name: | NALP4_HUMAN |
