Nkx2-2 Antibody (PACO28574)
- SKU:
- PACO28574
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | Nkx2-2 Antibody (PACO28574) |
| Antibody SKU: | PACO28574 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Homeobox protein Nkx-2.2 protein (1-273AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. |
| Synonyms: | Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B), Nkx2-2, Nkx-2.2 Nkx2b |
| UniProt Protein Function: | NKX2-2: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. Belongs to the NK-2 homeobox family.Protein type: Cell development/differentiation; Transcription factorCellular Component: intracellular; nucleusMolecular Function: chromatin binding; DNA binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor bindingBiological Process: astrocyte differentiation; cell development; cell differentiation; endocrine pancreas development; gut development; multicellular organismal development; negative regulation of neuron differentiation; nervous system development; neuron fate specification; oligodendrocyte development; positive regulation of cell differentiation; positive regulation of neuron differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell differentiation; regulation of transcription, DNA-dependent; smoothened signaling pathway; spinal cord motor neuron differentiation; spinal cord oligodendrocyte cell differentiation; spinal cord oligodendrocyte cell fate specification; transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P42586 |
| NCBI GenInfo Identifier: | 6754860 |
| NCBI Gene ID: | 18088 |
| NCBI Accession: | NP_035049.1 |
| UniProt Secondary Accession: | P42586 |
| UniProt Related Accession: | P42586 |
| Molecular Weight: | 46.1 kDa |
| NCBI Full Name: | homeobox protein Nkx-2.2 isoform 1 |
| NCBI Synonym Full Names: | NK2 homeobox 2 |
| NCBI Official Symbol: | Nkx2-2 |
| NCBI Official Synonym Symbols: | Nkx2.2; tinman; Nkx-2.2 |
| NCBI Protein Information: | homeobox protein Nkx-2.2 |
| UniProt Protein Name: | Homeobox protein Nkx-2.2 |
| UniProt Synonym Protein Names: | Homeobox protein NK-2 homolog B |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | Nkx2-2 |
| UniProt Entry Name: | NKX22_MOUSE |
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