NEDD8 Antibody, Biotin conjugated (PACO64058)
- SKU:
- PACO64058
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
| Antibody Name: | NEDD8 Antibody?Biotin conjugated (PACO64058) |
| Antibody SKU: | PACO64058 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human NEDD8 protein (81AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Antigen Affinity purified & Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Biotin |
| Background: | Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. |
| Synonyms: | NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8), NEDD8 |
| UniProt Protein Function: | NEDD8: a member of the ubiquitin family of proteins. Approximately 60% identical to ubiquitin protein. Activated by an E1-like complex, consisting of App-b1 and Uba3 and then linked to the E2-like enzyme, Ubc12. The major target protein modified by nedd8 is cullin-4a. Down-regulated during the development of brain. |
| UniProt Protein Details: | Protein type:Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 14q12 Cellular Component: cytosol; nucleus Molecular Function:protein binding; ubiquitin protein ligase binding Biological Process: regulation of transcription from RNA polymerase II promoter; ubiquitin-dependent protein catabolic process; protein localization; anatomical structure morphogenesis; protein neddylation; transforming growth factor beta receptor signaling pathway; protein modification process; proteolysis; response to organic cyclic substance |
| UniProt Code: | Q15843 |
| NCBI GenInfo Identifier: | 2833270 |
| NCBI Gene ID: | 4738 |
| NCBI Accession: | Q15843.1 |
| UniProt Secondary Accession: | Q15843,Q3SXN8, Q6LES6, |
| UniProt Related Accession: | Q15843 |
| Molecular Weight: | 81 |
| NCBI Full Name: | NEDD8 |
| NCBI Synonym Full Names: | neural precursor cell expressed, developmentally down-regulated 8 |
| NCBI Official Symbol: | NEDD8 |
| NCBI Official Synonym Symbols: | NEDD-8 |
| NCBI Protein Information: | NEDD8; neddylin; ubiquitin-like protein Nedd8 |
| UniProt Protein Name: | NEDD8 |
| UniProt Synonym Protein Names: | Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8 |
| Protein Family: | NEDD8 |
| UniProt Gene Name: | NEDD8 |
| UniProt Entry Name: | NEDD8_HUMAN |
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