NACC1 Antibody (PACO21523)
- SKU:
- PACO21523
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | NACC1 Antibody (PACO21523) |
Antibody SKU: | PACO21523 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
Species Reactivity: | Human |
Immunogen: | Peptide sequence around aa.519~523(A-G-P-S-A) derived from Human NAC1 |
Form: | Liquid |
Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Rat and Mouse brain tissue using NAC1 Antibody. |
Background: | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. "A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival." |
Synonyms: | BEND8; NACC1; NAC-1; BTBD14B; FLJ37383 |
UniProt Protein Function: | NAC1: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1. Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. |
UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: nuclear body; nucleus Biological Process: negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; protein homooligomerization |
NCBI Summary: | This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q96RE7 |
NCBI GenInfo Identifier: | 74732694 |
NCBI Gene ID: | 112939 |
NCBI Accession: | Q96RE7.1 |
UniProt Related Accession: | Q96RE7 |
Molecular Weight: | 57,258 Da |
NCBI Full Name: | Nucleus accumbens-associated protein 1 |
NCBI Synonym Full Names: | nucleus accumbens associated 1 |
NCBI Official Symbol: | NACC1 |
NCBI Official Synonym Symbols: | NAC1; BEND8; NAC-1; BTBD30; BTBD14B |
NCBI Protein Information: | nucleus accumbens-associated protein 1 |
UniProt Protein Name: | Nucleus accumbens-associated protein 1 |
UniProt Synonym Protein Names: | BTB/POZ domain-containing protein 14B |
Protein Family: | Nucleus accumbens-associated protein |
UniProt Gene Name: | NACC1 |
UniProt Entry Name: | NACC1_HUMAN |