MYC Transcription Factor Activity Assay
- SKU:
- TFAB00138
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- MYC
- Reactivity:
- Human
- Mouse
- Rat
Description
MYC Transcription Factor Activity Assay
The MYC Transcription Factor Activity Assay Kit is a powerful tool for studying the activity of the MYC transcription factor in various biological samples. This kit provides researchers with high sensitivity and specificity, ensuring accurate and reliable results.The MYC transcription factor is known to play a critical role in regulating gene expression and promoting cell growth and proliferation. Dysregulation of MYC activity has been implicated in various diseases, including cancer and metabolic disorders, making it a valuable target for research and therapeutic development.
With this assay kit, researchers can investigate the impact of different factors on MYC activity, allowing for a better understanding of its role in disease pathogenesis. The MYC Transcription Factor Activity Assay Kit is suitable for use in a wide range of experimental settings and offers a convenient and efficient way to analyze MYC activity in biological samples.
| Product Name: | MYC Transcription Factor Activity Assay |
| Product Code: | TFAB00138 |
| Target: | MYC |
| Synonyms: | Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie MYC transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes. |
| UniProt Protein Details: | Protein type:DNA-binding; Nucleolus; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 8q24.21 Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus; cytosol Molecular Function:protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity Biological Process: oxygen transport; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; regulation of telomere maintenance; transcription, DNA-dependent; MAPKKK cascade; negative regulation of cell division; negative regulation of stress-activated MAPK cascade; negative regulation of monocyte differentiation; chromatin remodeling; ureteric bud branching; regulation of gene expression; negative regulation of fibroblast proliferation; energy reserve metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis Disease: Burkitt Lymphoma |
| NCBI Summary: | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01106 |
| NCBI GenInfo Identifier: | 127619 |
| NCBI Gene ID: | 4609 |
| NCBI Accession: | P01106.1 |
| UniProt Secondary Accession: | P01106,P01107, Q14026, A8WFE7, |
| UniProt Related Accession: | P01106 |
| Molecular Weight: | 439 |
| NCBI Full Name: | Myc proto-oncogene protein |
| NCBI Synonym Full Names: | v-myc avian myelocytomatosis viral oncogene homolog |
| NCBI Official Symbol: | MYC |
| NCBI Official Synonym Symbols: | MRTL; MYCC; c-Myc; bHLHe39 |
| NCBI Protein Information: | myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor |
| UniProt Protein Name: | Myc proto-oncogene protein |
| UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64 |
| Protein Family: | Myc protein |
| UniProt Gene Name: | MYC |
| UniProt Entry Name: | MYC_HUMAN |
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