MTMR3 Antibody (PACO62743)
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주문- SKU:
- PACO62743
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MTMR3 Antibody (PACO62743) |
Antibody SKU: | PACO62743 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Myotubularin-related protein 3 protein (652-899AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO62743 diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | Immunofluorescence staining of U251 cells with PACO62743 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. |
Synonyms: | Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) (Zinc finger FYVE domain-containing protein 10), MTMR3, KIAA0371 ZFYVE10 |
UniProt Protein Function: | MTMR3: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.3.48; EC 3.1.3.64; EC 3.1.3.95; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: cytoplasm; cytosol; extrinsic to membrane; membrane Molecular Function:phosphatidylinositol-3-phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity Biological Process: cellular response to glucose starvation; macroautophagy; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation |
NCBI Summary: | This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13615 |
NCBI GenInfo Identifier: | 33112668 |
NCBI Gene ID: | 8897 |
NCBI Accession: | Q13615.3 |
UniProt Secondary Accession: | Q13615,Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3, A5PL26, A7MD32 |
UniProt Related Accession: | Q13615 |
Molecular Weight: | 134kDa |
NCBI Full Name: | Myotubularin-related protein 3 |
NCBI Synonym Full Names: | myotubularin related protein 3 |
NCBI Official Symbol: | MTMR3 |
NCBI Official Synonym Symbols: | ZFYVE10; FYVE-DSP1 |
NCBI Protein Information: | myotubularin-related protein 3 |
UniProt Protein Name: | Myotubularin-related protein 3 |
UniProt Synonym Protein Names: | FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95 |
UniProt Gene Name: | MTMR3 |
Antibodies |
Anti-MTMR3 Antibody (CAB10806) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |