| UniProt Protein Function: | MRPL35: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]Protein type: Translation; MitochondrialChromosomal Location of Human Ortholog: 2p11.2Cellular Component: mitochondrial inner membrane; mitochondrial ribosome; mitochondrionMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis; translation |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NZE8 |
| NCBI GenInfo Identifier: | 124028627 |
| NCBI Gene ID: | 51318 |
| NCBI Accession: | Q9NZE8.3 |
| UniProt Secondary Accession: | Q9NZE8,Q658U7, Q8WWA2, A6NKV6, B2RB93 |
| UniProt Related Accession: | Q9NZE8 |
| Molecular Weight: | 19,192 Da |
| NCBI Full Name: | 39S ribosomal protein L35, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L35 |
| NCBI Official Symbol: | MRPL35 |
| NCBI Official Synonym Symbols: | L35mt; MRP-L35 |
| NCBI Protein Information: | 39S ribosomal protein L35, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L35, mitochondrial |
| UniProt Synonym Protein Names: | |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL35 |
| UniProt Entry Name: | RM35_HUMAN |
