MPP6 Antibody (PACO20845)

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SKU:
PACO20845
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Application:
ELISA
Application:
IHC
Antibody type:
Polyclonal
Conjugation:
Unconjugated
Frequently bought together:

Description

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Antibody Name:MPP6 Antibody (PACO20845)
Antibody SKU:PACO20845
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human MPP6
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20845(MPP6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20845(MPP6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).
Synonyms:membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
UniProt Protein Function:VAM-1: a membrane-associated of the MAGUK family. Interacts with Lin7, which localizes to postsynaptic densities of neurons and epithelial cell-cell junctions.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7p15

Molecular Function:protein binding

NCBI Summary:Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9NZW5
NCBI GenInfo Identifier:42560556
NCBI Gene ID:51678
NCBI Accession:Q9NZW5.2
UniProt Secondary Accession:Q9NZW5,Q9H0E1, A4D157,
UniProt Related Accession:Q9NZW5
Molecular Weight:61,117 Da
NCBI Full Name:MAGUK p55 subfamily member 6
NCBI Synonym Full Names:membrane palmitoylated protein 6
NCBI Official Symbol:MPP6  
NCBI Official Synonym Symbols:VAM1; p55T; PALS2; VAM-1  
NCBI Protein Information:MAGUK p55 subfamily member 6
UniProt Protein Name:MAGUK p55 subfamily member 6
UniProt Synonym Protein Names:Veli-associated MAGUK 1; VAM-1
Protein Family:MAGUK p55 subfamily
UniProt Gene Name:MPP6  
UniProt Entry Name:MPP6_HUMAN
AntibodiesELISA Kits
Anti-MPP6 Antibody (CAB10509)Human VAM1 / MPP6 / MAGUK p55 subfamily member 6 ELISA Kit
MPP6 Antibody (PACO10557)Human MAGUK p55 subfamily member 6 (MPP6) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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