Mouse UCHL1 Recombinant Protein (RPPB5077)

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SKU:
RPPB5077
Product type:
Recombinant Protein
Size:
10ug
Species:
Mouse
Target:
UCHL1
Synonyms:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1
Synonyms:
Neuron cytoplasmic protein 95
Synonyms:
PGP 95
Source:
Escherichia Coli
Uniprot:
Q9R0P9
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Description

Product Name:Mouse UCHL1 Recombinant Protein
Product Code:RPPB5077
Size:10µg
Species:Mouse
Target:UCHL1
Synonyms:Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1,Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:UCHL1 protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMQLKPME INPEMLNKVL AKLGVAGQWR FADVLGLEEE TLGSVPSPAC ALLLLFPLTA QHENFRKKQI EELKGQEVSP KVYFMKQTIG NSCGTIGLIH AVANNQDKLE FEDGSVLKQF LSETEKLSPE DRAKCFEKNE AIQAAHDSVA QEGQCRVDDK VNFHFILFNN VDGHLYELDG RMPFPVNHGA SSEDSLLQDA AKVCREFTER EQGEVRFSAV ALCKAA
Biological Activity:Specific activity is > 70 pmol/min/ug, and is defined as the amount of enzyme that hydrolysis 1.0 pmole of ubiquitin-AMC per minute at pH 7.5, at 37°C.

UbiquitinCarboxyl-Terminal Esterase L1 (UCHL1) is a part of a family whose productshydrolyze small C-terminal adducts of ubiquitin to create the ubiquitin monomer.UCHL1 is a part of the ubiquitin system, which regulates many biologicalactivities. UCHL1 is a thiol protease that distinguishes and hydrolyzes apeptide bond at the C-terminal glycine of ubiquitin. UCHL1 binds to free monoubiquitinand avoids its degradation in lysosomes.

UCHL1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 246 amino acids (1-223 a.a) and having a molecular mass of 27.2kDa.UCHL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
UniProt Code:Q9R0P9
NCBI GenInfo Identifier:18203410
NCBI Gene ID:22223
NCBI Accession:Q9R0P9.1
UniProt Secondary Accession:Q9R0P9,Q9R122,
UniProt Related Accession:Q9R0P9
Molecular Weight:24,838 Da
NCBI Full Name:Ubiquitin carboxyl-terminal hydrolase isozyme L1
NCBI Synonym Full Names:ubiquitin carboxy-terminal hydrolase L1
NCBI Official Symbol:Uchl1  
NCBI Official Synonym Symbols:gad; C88048; PGP9.5; R75593; UCH-L1; UCHL-1; PGP 9.5; AW822034  
NCBI Protein Information:ubiquitin carboxyl-terminal hydrolase isozyme L1
UniProt Protein Name:Ubiquitin carboxyl-terminal hydrolase isozyme L1
UniProt Synonym Protein Names:Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1
UniProt Gene Name:Uchl1  
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