Mouse TSLP Recombinant Protein (RPPB1046)
- SKU:
- RPPB1046
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Mouse
- Target:
- TSLP
- Synonyms:
- Thymic Stromal Lymphopoietin
- TSLP
- Source:
- Sf9 Insect cells
- Uniprot:
- Q9JIE6
Description
| Product Name: | Mouse TSLP Recombinant Protein |
| Product Code: | RPPB1046 |
| Size: | 5µg |
| Species: | Mouse |
| Target: | TSLP |
| Synonyms: | Thymic Stromal Lymphopoietin, TSLP. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TSLP solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPYNFSNCN FTSITKIYCN IIFHDLTGDL KGAKFEQIED CESKPACLLK IEYYTLNPIPGCPSLPDKTF ARRTREALND HCPGYPETER NDGTQEMAQE VQNICLNQTS QILRLWYSFM QSPEHHHHHH |
TSLP protein is a hemopoietic cytokine which signals throughout a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor & the Interleukin-7 receptor alpha chain. TSLP impacts myeloid cells thus induces the discharge of T cell-attracting chemokines from monocytes & increases the growth of CD11c(+) dendritic cells. TSLP is mainly expressed in the heart, liver and prostate. TSLP is related in its biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the Interleukin-7 receptor alpha chain & the TSLPR. Similar to IL-7, TSLP enhances phosphorylation of STAT3 and STAT5, though uses kinases excluding JAKs for its activation. TSLP induces the release of T cell-attracting chemokines such asTARC & MDC from monocytes & triggers CD11c(+) dendritic cells. TSLP activated dendritic cells primes naive T cells to manufacture pro-allergic cytokines such as Iinterleukin-4, Interleukin-5, Interleukin-13 and TNF-alpha whereas down-regulating Interleukin-10 and IFN-gamma play a role in the initiation of allergic inflammation.
TSLP Mouse Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 130 amino acids (20-140aa) and having a molecular mass of 15.0kDa.TSLP is fused to a 29 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TSLP: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function:cytokine activity |
| UniProt Code: | Q9JIE6 |
| NCBI GenInfo Identifier: | 81868532 |
| NCBI Gene ID: | 53603 |
| NCBI Accession: | Q9JIE6.1 |
| UniProt Related Accession: | Q9JIE6 |
| Molecular Weight: | Predicted Molecular Mass: 24kDaAccurate Molecular Mass: 26kDa |
| NCBI Full Name: | Thymic stromal lymphopoietin |
| NCBI Synonym Full Names: | thymic stromal lymphopoietin |
| NCBI Official Symbol: | Tslp |
| NCBI Protein Information: | thymic stromal lymphopoietin |
| UniProt Protein Name: | Thymic stromal lymphopoietin |
| UniProt Synonym Protein Names: | Thymic stroma-derived lymphopoietin |
| Protein Family: | Thymic stromal lymphopoietin |
| UniProt Gene Name: | Tslp |
| UniProt Entry Name: | TSLP_MOUSE |
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