Mouse TPT1 Recombinant Protein (RPPB4997)
- SKU:
- RPPB4997
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Mouse
- Target:
- TPT1
- Synonyms:
- Translationally-controlled tumor protein
- TCTP
- 21 kDapolypeptide
- p21
- Source:
- Escherichia Coli
- Uniprot:
- P63028
Description
| Product Name: | Mouse TPT1 Recombinant Protein |
| Product Code: | RPPB4997 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | TPT1 |
| Synonyms: | Translationally-controlled tumor protein, TCTP, 21 kDapolypeptide, p21, p23. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TPT1 protein solution (1mg/ml) containing PhosphateBuffered Saline, 10% glycerolAnd 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMMIIYR DLISHDELFS DIYKIREIAD GLCLEVEGKM VSRTEGAIDDSLIGGNASAE GPEGEGTEST VVTGVDIVMN HHLQETSFTK EAYKKYIKDY MKSLKGKLEE QKPERVKPFMTGAAEQIKHI LANFNNYQFF IGENMNPDGM VALLDYREDG VTPFMIFFKD GLEMEKC |
TPT1 takes part in calcium binding and microtubule stabilization. TPT1 is an immunoglobulin E dependent histamine-releasing factor produced by lymphocytes of atopic children and present in biologic fluids of allergic patients. TPT1 protein is similar to p23, a protein of Ehrlich ascites tumor cells, synthesized in the exponentially growing tumor. TPT1 is similar with IgE-dependent histamine releasing factor. TPT1 has a cell housekeeping function. TPT1 is involved in spermatogenesis and acts as a calcium binding protein of the human placenta that regulates calcium handling in trophoblast cells.
TPT1 Mouse Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 197 amino acids (1-172 a.a) andhaving a molecular mass of 22.1kDa.TPT1 is fused to a 25 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TPT1: a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation.Protein type: Calcium-binding; Microtubule-bindingCellular Component: cytoplasm; extracellular space; multivesicular body; nucleoplasm; nucleus; tubulin complexMolecular Function: calcium ion binding; microtubule binding; transcription factor bindingBiological Process: cell differentiation; stem cell maintenance |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P63028 |
| NCBI GenInfo Identifier: | 6678437 |
| NCBI Gene ID: | 22070 |
| NCBI Accession: | NP_033455.1 |
| UniProt Secondary Accession: | P63028,P14701, Q3TMT0, Q3TWS8, Q3TWX0, Q3UAG7, Q569M9 |
| UniProt Related Accession: | P63028 |
| Molecular Weight: | 19,462 Da |
| NCBI Full Name: | translationally-controlled tumor protein |
| NCBI Synonym Full Names: | tumor protein, translationally-controlled 1 |
| NCBI Official Symbol: | Tpt1 |
| NCBI Official Synonym Symbols: | Trt; p21; p23; TCTP |
| NCBI Protein Information: | translationally-controlled tumor protein |
| UniProt Protein Name: | Translationally-controlled tumor protein |
| UniProt Synonym Protein Names: | 21 kDa polypeptide; p21; p23 |
| Protein Family: | Translationally-controlled tumor protein |
| UniProt Gene Name: | Tpt1 |
| UniProt Entry Name: | TCTP_MOUSE |
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