Mouse SRC Kinase/c-SRC Recombinant Protein (RPES1995)
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- SKU:
- RPES1995
- Product type:
- Recombinant Protein
- Host species:
- Baculovirus-Insect Cells
- Reactivity:
- Mouse
Frequently bought together:
Description
system_update_alt데이터시트
Mouse SRC Kinase/c-SRC Recombinant Protein
Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is a constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.
| Product Name: | Mouse SRC Kinase/c-SRC Recombinant Protein (RPES1995) |
| Product Code: | RPES1995 |
| Size: | 20µg |
| Species: | Mouse |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | AW259666,pp60c-src |
| Accession: | NP_001020566.111 |
| Sequence: | Met 1-Leu 535 |
| Fusion tag: | N-His-GST |
| Activity: | 1. The specific activity was determined to be ?80 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate.2. Measured by its binding ability in a functional ELISA. Immobilized recombinant Mouse SRC at 2 µg/ml (100 ?l/well) can bind biotinylated human PTPRA (aa 174-793) with a linear range of 0.032-0.8 µg/ml. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mouse SRC (NP_001020566.111) (Met 1-Leu 535) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 87.7 kDa |
| AP Mol Mass: | 80 kDa |
| Formulation: | Supplied as sterile 20mM Tris, 500mM NaCl, 10% gly, pH 8.0 |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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