Mouse SNCA Recombinant Protein (RPPB4739)
- SKU:
- RPPB4739
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Mouse
- Target:
- SNCA
- Synonyms:
- Alpha-synuclein
- Non-A beta component of AD amyloid
- Non-A4 component of amyloid precursor
- NACP
- Source:
- Escherichia Coli
- Uniprot:
- O55042
Description
| Product Name: | Mouse SNCA Recombinant Protein |
| Product Code: | RPPB4739 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | SNCA |
| Synonyms: | Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4, MGC110988, ?-Synuclein, SNCA, Syn, SNCA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The SNCA protein contains 20mM Tris-HCl buffer (pH 7.5) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA |
a-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. a-synuclein has been suggested to be implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that a-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).
SNCA Recombinant Mouse produced in E.Coli is a single, non-glycosylated polypeptide chain containing 140 amino acids (1-140 a.a.) and having a molecular mass of 14.4 kDa. The SNCA is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | May be involved in the regulation of dopamine release and transport. |
| UniProt Code: | O55042 |
| NCBI GenInfo Identifier: | 6678047 |
| NCBI Gene ID: | 20617 |
| NCBI Accession: | NP_033247 |
| UniProt Secondary Accession: | O55042,Q3U130, Q9CXF8, Q9EQC3, Q9QUR3, |
| UniProt Related Accession: | O55042 |
| Molecular Weight: | 14.4 kDa (140aa), confirmed by MALDI-TOF |
| NCBI Full Name: | alpha-synuclein |
| NCBI Synonym Full Names: | synuclein, alpha |
| NCBI Official Symbol: | Snca |
| NCBI Official Synonym Symbols: | NACP; alphaSYN; alpha-Syn |
| NCBI Protein Information: | alpha-synuclein |
| UniProt Protein Name: | Alpha-synuclein |
| UniProt Synonym Protein Names: | Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP |
| Protein Family: | Alpha-synuclein |
| UniProt Gene Name: | Snca |
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