Mouse SHP2/PTPN11 Recombinant Protein (RPES2038)
- SKU:
- RPES2038
- Product type:
- Recombinant Protein
- Host species:
- HEK293 Cells
- Reactivity:
- Mouse
Frequently bought together:
Description
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Mouse SHP2/PTPN11 Recombinant Protein
SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
| Product Name: | Mouse SHP2/PTPN11 Recombinant Protein (RPES2038) |
| Product Code: | RPES2038 |
| Size: | 100µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | 2700084A17Rik,AW536184,PTP1D,PTP2C,SAP-2,SH-PTP2,SH-PTP3,SHP-2,Shp2,Syp |
| Accession: | P35235-2 |
| Sequence: | Met1-Arg593 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site (Catalog # ES006).The specific activity is > 1 pmoles/min/µg. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mouse PTPN11 (P35235-2) (Met1-Arg593) was expressed with a C-terminal polyhistidine tag. |
| Purity: | > 90 % as determined by SDS-PAGE |
| Mol Mass: | 69.5 kDa |
| AP Mol Mass: | 65 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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