Mouse SERPINF2 Recombinant Protein (RPPB4644)
- SKU:
- RPPB4644
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Mouse
- Target:
- SERPINF2
- Synonyms:
- Alpha-2-antiplasmin
- Alpha-2-AP
- Alpha-2-plasmininhibitor
- Alpha-2-PI
- Source:
- Sf9 Insect cells
- Uniprot:
- Q61247
Description
| Product Name: | Mouse SERPINF2 Recombinant Protein |
| Product Code: | RPPB4644 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | SERPINF2 |
| Synonyms: | Alpha-2-antiplasmin, Alpha-2-AP, Alpha-2-plasmininhibitor, Alpha-2-PI, Serpin F2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SERPINF2 protein solution (1mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | VDLPGQQPVS EQAQQKLPLP ALFKLDNQDF GDHATLKRSP GHCKSVPTAEETRRLAQAMM AFTTDLFSLV AQTSTSSNLV LSPLSVALAL SHLALGAQNQ TLHSLHRVLH MNTGSCLPHLLSHFYQNLGP GTIRLAARIY LQKGFPIKDD FLEQSERLFG AKPVKLTGKQ EEDLANINQW VKEATEGKIEDFLSELPDST VLLLLNAIHF HGFWRTKFDP SLTQKDFFHL DERFTVSVDM MHAVSYPLRW FLLEQPEIQVAHFPFKNNMS FVVVMPTYFE WNVSEVLANL TWDTLYHPSL QERPTKVWLP KLHLQQQLDL VATLSQLGLQELFQGPDLRG ISEQNLVVSS VQHQSTMELS EAGVEAAAAT SVAMNRMSLS SFTVNRPFLF FIMEDTIGVPLFVGSVRNPN PSALPQLQEQ RDSPDNRLIG QNDKADFHGG KTFGPDLKLA PRMEEDYPQF SSPKHHHHHH |
Alpha-2-antiplasmin (SERPINF2) is a serine protease inhibitor. The main targets of SERPINF2 are plasmin and trypsin; however SERPINF2 also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
SERPINF2 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 470 amino acids (28-491 a.a.) andhaving a molecular mass of 52.9kDa (Migrates at 70-100kDa on SDS-PAGE underreducing conditions).SERPINF2 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SERPINF2: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID). APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis. Belongs to the serpin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein homodimerization activity; protease binding; protease inhibitor activity Biological Process: collagen fibril organization; negative regulation of fibrinolysis; renin-angiotensin regulation of blood vessel size; positive regulation of smooth muscle cell proliferation; positive regulation of stress fiber formation; positive regulation of collagen biosynthetic process; acute-phase response; blood vessel morphogenesis; negative regulation of peptidase activity; positive regulation of JNK cascade; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation Disease: Alpha-2-plasmin Inhibitor Deficiency |
| UniProt Code: | Q61247 |
| NCBI GenInfo Identifier: | 6679383 |
| NCBI Gene ID: | 18816 |
| NCBI Accession: | NP_032904.1 |
| UniProt Related Accession: | Q61247 |
| Molecular Weight: | 17.3kDa |
| NCBI Full Name: | alpha-2-antiplasmin |
| NCBI Synonym Full Names: | serine (or cysteine) peptidase inhibitor, clade F, member 2 |
| NCBI Official Symbol: | Serpinf2 |
| NCBI Official Synonym Symbols: | Pli; AI747498; Serpimf2 |
| NCBI Protein Information: | alpha-2-antiplasmin; serpin F2; alpha-2-AP; alpha-2-PI; alpha 2 antiplasmin; alpha-2-plasmin inhibitor; plasmin inhibitor alpha 2; pigment epithelium derived factor; serine (or cysteine) proteinase inhibitor, clade F, member 2 |
| UniProt Protein Name: | Alpha-2-antiplasmin |
| UniProt Synonym Protein Names: | Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2 |
| UniProt Gene Name: | Serpinf2 |
| UniProt Entry Name: | A2AP_MOUSE |
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