Mouse SERPINE2 Recombinant Protein (RPPB2271)
- SKU:
- RPPB2271
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Mouse
- Target:
- SERPINE2
- Synonyms:
- Serpnie2
- B230326M24Rik
- PAI-1
- PI-7
- Source:
- Sf9 Insect cells
- Uniprot:
- Q07235
Description
| Product Name: | Mouse SERPINE2 Recombinant Protein |
| Product Code: | RPPB2271 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | SERPINE2 |
| Synonyms: | Serpnie2, B230326M24Rik, PAI-1, PI-7, PI7, PN-1, Spi4, Glia-derivednexin, GDN,Peptidase inhibitor 7, Protease nexin 1, Protease nexin I, Serineprotease-inhibitor 4, Serpin E2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SERPINE2 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | SQFNSLSLEE LGSNTGIQVF NQIIKSRPHE NVVVSPHGIA SILGMLQLGADGKTKKQLST VMRYNVNGVG KVLKKINKAI VSKKNKDIVT VANAVFLRNG FKMEVPFAVR NKDVFQCEVQNVNFQDPASA SESINFWVKN ETRGMIDNLL SPNLIDGALT RLVLVNAVYF KGLWKSRFQP ESTKKRTFVAGDGKSYQVPM LAQLSVFRSG STRTPNGLWY NFIELPYHGE SISMLIALPT ESSTPLSAII PHITTKTIDSWMNTMVPKRM QLVLPKFTAV AQTDLKEPLK ALGITEMFEP SKANFTKITR SESLHVSHIL QKAKIEVSEDGTKASAATTA ILIARSSPPW FIVDRPFLFS IRHNPTGAIL FLGQVNKPLE HHHHHH |
PlasminogenActivator Inhibitor-2 (Serpine2) which inhibits thrombin, plasmin andplasminogen activators is a part of the Serpin superfamily of the serineprotease inhibitors. Serpine2 is able to transform human embryonic kidney cellsinto neuron-like cells. Furthermore, Serpine2's over expression in mice leadsto progressive neuronal and motor dysfunction.
SERPINE2 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 386 amino acids (20-397a.a.) andhaving a molecular mass of 42.9kDa (Molecular size on SDS-PAGE will appear atapproximately 40-57kDa).SERPINE2 is expressed with a 8 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SERPINE2: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Inhibitor; Secreted, signal peptide Cellular Component: extracellular matrix; extracellular space; extrinsic to external side of plasma membrane; membrane; cell soma; cell; extracellular region; cytosol; neuromuscular junction; vesicle Molecular Function:serine-type endopeptidase inhibitor activity; heparin binding; glycosaminoglycan binding; protease inhibitor activity; receptor binding Biological Process: negative regulation of proteolysis; nervous system development; regulation of synaptic transmission, glutamatergic; secretory granule organization and biogenesis; multicellular organismal development; cerebellar granular layer morphogenesis; negative regulation of peptidase activity; negative regulation of blood coagulation; mating plug formation; detection of mechanical stimulus involved in sensory perception; negative regulation of cell proliferation; negative regulation of smoothened signaling pathway; response to wounding; negative regulation of cell growth; blood coagulation; cell differentiation; negative regulation of protein catabolic process; regulation of timing of cell differentiation; negative regulation of phosphoinositide 3-kinase cascade; positive regulation of astrocyte differentiation; secretion by cell |
| UniProt Code: | Q07235 |
| NCBI GenInfo Identifier: | 6678099 |
| NCBI Gene ID: | 20720 |
| NCBI Accession: | NP_033281.1 |
| UniProt Secondary Accession: | Q07235,Q921T7, |
| UniProt Related Accession: | Q07235 |
| Molecular Weight: | 44,207 Da |
| NCBI Full Name: | glia-derived nexin |
| NCBI Synonym Full Names: | serine (or cysteine) peptidase inhibitor, clade E, member 2 |
| NCBI Official Symbol: | Serpine2 |
| NCBI Official Synonym Symbols: | PI7; PI-7; PN-1; Spi4; PAI-1; B230326M24Rik |
| NCBI Protein Information: | glia-derived nexin; GDN; serpin E2; protease nexin 1; protease nexin I; peptidase inhibitor 7; serine protease inhibitor 4; serine protease-inhibitor 4; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 |
| UniProt Protein Name: | Glia-derived nexin |
| UniProt Synonym Protein Names: | Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serine protease-inhibitor 4; Serpin E2 |
| Protein Family: | Glia-derived nexin |
| UniProt Gene Name: | Serpine2 |
| UniProt Entry Name: | GDN_MOUSE |
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