Mouse SERPINA6 Recombinant Protein (RPPB4631)

Serpin Peptidase Inhibitor, Clade A Member 6 (SERPINA6) is a member of the serpin superfamily. SERPINA6 is synthesized and secreted by hepatocytes in the liver and is found in glycocorticoid responsive cells. The concentration of SERPINA6 is regulated by estrogens. SERPINA6 is the main transport protein for progestins and glucocorticoids within the blood. Therefore SERPINA6 regulates their bioavailability and metabolic clearance and protects them from absorption into cells and degradation by chemicals and enzymes. SERPINA6 contains a single steroid binding site with high affinity for cortisol and progesterone. Approximately 80-90% of circulating cortisol is bound to SERPINA6. The SERPINA6 bound cortisol is considered to be biologically inactive, whereas the unbound cortisol constitutes the active form of cortisol. The active portion of plasma cortisol will therefore depend on the concentration of SERPINA6. SERPINA6 gene defects cause the corticosteroid binding globulin deficiency (CBG deficiency), a rare disorder characterized by reduced CBG production which results in hypo/ hypertension and muscle fatigue.

SERPINA6 Mouse Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Val23-Ala397) containing a total of 384 amino acids, having a calculated molecular mass of 43.5kDa and fused to a 9 aa His tag at C-Terminus.