Mouse PODXL Recombinant Protein (RPPB4268)
- SKU:
- RPPB4268
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Mouse
- Target:
- PODXL
- Synonyms:
- Podocalyxin
- Podocalyxin-like protein 1
- PC
- PCLP-1
- Source:
- Sf9 Insect cells
- Uniprot:
- Q9R0M4
Description
| Product Name: | Mouse PODXL Recombinant Protein |
| Product Code: | RPPB4268 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | PODXL |
| Synonyms: | Podocalyxin,Podocalyxin-like protein 1, PC, PCLP-1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | PODXL protein solution (0.5mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | HNGNETSTSA IKSSTVQSHQ SATTSTEVTT GHPVASTLAS TQPSNPTPFTTSTQSPSMPT STPNPTSNQS GGNLTSSVSE VDKTKTSSPS STAFTSSSGQ TASSGGKSGD SFTTAPTTTLGLINVSSQPT DLNTTSKLLS TPTTDNTTSP QQPVDSSPST ASHPVGQHTP AAVPSSSGSTPSTDNSTLTW KPTTHKPLGT SEATQPLTSQ TPGITTLPVS TLQQSMASTVGTTTEEFTHL ISNGTPVAPP GPSTPSPIWA FGNYQLNCEP PIRPDEELLI LNLTRASLCE RSPLDEKEKLVELLCHSVKA SFKPAEDLCT LHVAPILDNQ AVAVKRIIIE TKLSPKAVYE LLKDRWDDLTEAGVSDMKLG KEGPPEVNED RFSLEHHHHH H |
Podocalyxin (PODXL) is a greatly glycosylated transmembrane sialoprotein in the CD34 and endoglycan family. The PODXL protein is involved in the regulation of both adhesion and cell morphology and cancer progression. PODXL functions as an anti-adhesive molecule, which retains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Moreover, PODXL serves as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner.
PODXL Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 391 amino acids (22-404a.a.) and having a molecular mass of 41.0kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). PODXL is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PODXL: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. Belongs to the podocalyxin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 6 A3.3|6 12.57 cM Cellular Component: apical plasma membrane; microvillus membrane; plasma membrane Biological Process: cell migration; leukocyte migration; negative regulation of cell adhesion; negative regulation of cell-cell adhesion; regulation of microvillus biogenesis |
| UniProt Code: | Q9R0M4 |
| NCBI GenInfo Identifier: | 17369446 |
| NCBI Gene ID: | 27205 |
| NCBI Accession: | Q9R0M4.2 |
| UniProt Secondary Accession: | Q9R0M4,Q9ESZ1, |
| UniProt Related Accession: | Q9R0M4 |
| Molecular Weight: | 41 kDa |
| NCBI Full Name: | Podocalyxin |
| NCBI Synonym Full Names: | podocalyxin-like |
| NCBI Official Symbol: | Podxl |
| NCBI Official Synonym Symbols: | PC; Ly102; Pclp1; PCLP-1; Podxl1; AW121214 |
| NCBI Protein Information: | podocalyxin |
| UniProt Protein Name: | Podocalyxin |
| UniProt Synonym Protein Names: | Podocalyxin-like protein 1; PC; PCLP-1 |
| Protein Family: | Podocalyxin |
| UniProt Gene Name: | Podxl |
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