Purified Anti-Mouse CD161/NK1.1 Antibody [PK136] (AGEL0010)

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SKU:
AGEL0010
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PK136
Conjugation:
Unconjugated
Applications:
FC
IHC
IF
IP
Frequently bought together:

Description

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Purified Anti-Mouse CD161/NK1.1 Antibody [PK136]

The Mouse NK1.1 Monoclonal Antibody (PK136) is designed for research involving NK1.1, a critical cell surface molecule expressed by natural killer (NK) cells and involved in regulating immune responses. This monoclonal antibody, generated in mice, is highly reactive with mouse samples and is validated for use in flow cytometry applications. It binds to the NK1.1 antigen, enabling precise detection and analysis of NK cells in various tissues, making it ideal for studies in immunology and cancer research.NK1.1, also known as NKR-P1C, plays a fundamental role in immune surveillance, tumor eradication, and modulation of adaptive immune responses. Its significance in immune regulation makes it a valuable target for research into diseases such as cancer, infectious diseases, and autoimmune disorders.

The Mouse NK1.1 Monoclonal Antibody (PK136) is essential for researchers aiming to understand NK cell function and develop therapies that harness or modulate immune activity in these contexts.By providing accurate and reliable detection of NK1.1, this antibody supports in-depth studies of NK cell-mediated immune responses, contributing to the advancement of therapeutic strategies for cancer and other immune-related conditions. Understanding the activity of NK1.1 is crucial for the development of novel immunotherapies that leverage NK cell function to improve treatment outcomes.

Product Title:Purified Anti-Mouse CD161/NK1.1 Antibody [PK136]
SKU:AGEL0010
Size:25µg, 100µg
Clone No:PK136
Synonyms:Killer cell lectin-like receptor subfamily B member 1C;Klrb1c;CD161 antigen-like family member C;Ly-55c;CD161/NK1.1;NKR-P1.9;NKR-P1C;NKR-P1 40;CD161c;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Purified Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P27814 P27812 Q99JB4
Gene ID:17059
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

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