Biotin Anti-Mouse CD161/NK1.1 Antibody [PK136] (AGEL0011)

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SKU:
AGEL0011
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PK136
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Mouse CD161/NK1.1 Antibody [PK136]

The Mouse NK1.1 Monoclonal Antibody, Biotin Conjugated (PK136) is designed for advanced research involving NK1.1, a key cell surface molecule expressed by natural killer (NK) cells that plays a crucial role in immune regulation. This monoclonal antibody, raised in mice, is highly reactive with mouse samples and is validated for use in flow cytometry and immunohistochemistry applications. The biotin conjugation enables enhanced detection and quantification with various biotin-avidin/streptavidin-based assay systems.NK1.1, also known as NKR-P1C, is essential for immune surveillance, tumor eradication, and the modulation of adaptive immune responses. Its pivotal role in immune regulation makes it a valuable target for research into diseases such as cancer, infectious diseases, and autoimmune disorders.

The Mouse NK1.1 Monoclonal Antibody, Biotin Conjugated (PK136), facilitates precise identification and analysis of NK cells, supporting detailed studies of NK cell function and development.Understanding the activity of NK1.1 is fundamental for developing therapies that harness or modulate NK cell function, making this antibody an indispensable tool for researchers in immunology and oncology. By enabling accurate detection of NK cells, it contributes to the advancement of immunotherapeutic strategies for treating cancer and improving immune responses in various pathological conditions.

Product Title:Biotin Anti-Mouse CD161/NK1.1 Antibody [PK136]
SKU:AGEL0011
Size:25µg, 100µg
Clone No:PK136
Synonyms:Killer cell lectin-like receptor subfamily B member 1C;Klrb1c;CD161 antigen-like family member C;Ly-55c;CD161/NK1.1;NKR-P1.9;NKR-P1C;NKR-P1 40;CD161c;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Biotin Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P27814 P27812 Q99JB4
Gene ID:17059
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

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