APC Anti-Mouse CD161/NK1.1 Antibody [PK136] (AGEL0014)

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SKU:
AGEL0014
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PK136
Conjugation:
APC
Applications:
FC
Frequently bought together:

Description

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APC Anti-Mouse CD161/NK1.1 Antibody [PK136]

The Mouse NK1.1 Monoclonal Antibody, APC Conjugated (PK136) is specifically designed for research targeting NK1.1, a crucial cell surface molecule expressed by natural killer (NK) cells involved in immune regulation. This monoclonal antibody, developed in mice, is conjugated with allophycocyanin (APC), providing strong and stable red fluorescence for accurate detection in flow cytometry applications.NK1.1, also known as NKR-P1C, plays a vital role in immune surveillance, tumor eradication, and the modulation of adaptive immune responses. The importance of NK1.1 in immune regulation makes it an invaluable target for studying diseases such as cancer, infectious diseases, and autoimmune disorders.

The Mouse NK1.1 Monoclonal Antibody, APC Conjugated (PK136), enables precise identification and comprehensive analysis of NK cells, supporting cutting-edge research in immunology and oncology.Understanding the function and activity of NK1.1 is essential for developing therapies that harness or modulate NK cell function. This antibody is an indispensable resource for researchers aiming to elucidate NK cell mechanisms and advance therapeutic strategies for cancer and immune-related diseases. By offering precise detection of NK1.1, this antibody significantly contributes to the development of novel immunotherapies and improved treatment outcomes.

Product Title:APC Anti-Mouse CD161/NK1.1 Antibody [PK136]
SKU:AGEL0014
Size:50 Tests, 100 Tests, 200 Tests
Clone No:PK136
Synonyms:Killer cell lectin-like receptor subfamily B member 1C;Klrb1c;CD161 antigen-like family member C;Ly-55c;CD161/NK1.1;NKR-P1.9;NKR-P1C;NKR-P1 40;CD161c;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:APC Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P27814 P27812 Q99JB4
Gene ID:17059
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

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