Mouse MYDGF Recombinant Protein (RPPB0776)
- SKU:
- RPPB0776
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Mouse
- Target:
- MYDGF
- Synonyms:
- D17Wsu104e
- Il25
- Ly6elg
- MYDGF
- Source:
- Escherichia Coli
- Uniprot:
- Q9CPT4
Description
| Product Name: | Mouse MYDGF Recombinant Protein |
| Product Code: | RPPB0776 |
| Size: | 5µg |
| Species: | Mouse |
| Target: | MYDGF |
| Synonyms: | D17Wsu104e, Il25, Ly6elg, MYDGF, Interleukin-25, IL-25, Stromal cell-derived growth factor SF20. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | MYDGF protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.0), 0.1M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSVSEPTTV PFDVRPGGVV HSFSQDVGPG NKFTCTFTYA SQGGTNEQWQ MSLGTSEDSQ HFTCTIWRPQ GKSYLYFTQF KAELRGAEIE YAMAYSKAAF ERESDVPLKS EEFEVTKTAV SHRPGAFKAE LSKLVIVAKA ARSEL |
Myeloid-derived growth factor (Mydgf) is a paracrine-acting protein and a bone marrow-derived monocyte which stimulates cardiac myocyte survival and adaptive angiogenesis for cardiac protection and repair after myocardial infarction. Mydgf induces endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling lane. When comparing wild-type mice to mice with a Mydgf-deficiency, the later develop larger infarct scars and more acute contractile dysfunction.
MYDGF Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (25-166 a.a) and having a molecular mass of 18.1kDa.MYDGF is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MYDGF: was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Cellular Component: extracellular space; extracellular region Biological Process: positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; positive regulation of MAPKKK cascade; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was identified in error as interleukin 25. This activity has not been reproducible, however, and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9CPT4 |
| NCBI GenInfo Identifier: | 61221740 |
| NCBI Gene ID: | 28106 |
| NCBI Accession: | Q9CPT4.1 |
| UniProt Secondary Accession: | Q9CPT4,Q3UG74, A2RSI7, |
| UniProt Related Accession: | Q9CPT4 |
| Molecular Weight: | 17,982 Da |
| NCBI Full Name: | UPF0556 protein C19orf10 homolog |
| NCBI Synonym Full Names: | DNA segment, Chr 17, Wayne State University 104, expressed |
| NCBI Official Symbol: | D17Wsu104e |
| NCBI Official Synonym Symbols: | Il25; Ly6elg |
| NCBI Protein Information: | UPF0556 protein C19orf10 homolog |
| UniProt Protein Name: | UPF0556 protein C19orf10 homolog |
| UniProt Synonym Protein Names: | Interleukin-25; IL-25; Stromal cell-derived growth factor SF20 |
| UniProt Gene Name: | D17Wsu104e |
| UniProt Entry Name: | CS010_MOUSE |
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