Mouse MYDGF Recombinant Protein (RPPB0776)

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SKU:
RPPB0776
Product type:
Recombinant Protein
Size:
5ug
Species:
Mouse
Target:
MYDGF
Synonyms:
D17Wsu104e
Synonyms:
Il25
Synonyms:
Ly6elg
Synonyms:
MYDGF
Source:
Escherichia Coli
Uniprot:
Q9CPT4
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Description

Product Name:Mouse MYDGF Recombinant Protein
Product Code:RPPB0776
Size:5µg
Species:Mouse
Target:MYDGF
Synonyms:D17Wsu104e, Il25, Ly6elg, MYDGF, Interleukin-25, IL-25, Stromal cell-derived growth factor SF20.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MYDGF protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.0), 0.1M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSVSEPTTV PFDVRPGGVV HSFSQDVGPG NKFTCTFTYA SQGGTNEQWQ MSLGTSEDSQ HFTCTIWRPQ GKSYLYFTQF KAELRGAEIE YAMAYSKAAF ERESDVPLKS EEFEVTKTAV SHRPGAFKAE LSKLVIVAKA ARSEL

Myeloid-derived growth factor (Mydgf) is a paracrine-acting protein and a bone marrow-derived monocyte which stimulates cardiac myocyte survival and adaptive angiogenesis for cardiac protection and repair after myocardial infarction. Mydgf induces endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling lane. When comparing wild-type mice to mice with a Mydgf-deficiency, the later develop larger infarct scars and more acute contractile dysfunction. 

MYDGF Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (25-166 a.a) and having a molecular mass of 18.1kDa.MYDGF is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MYDGF: was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Cellular Component: extracellular space; extracellular region

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; positive regulation of MAPKKK cascade; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis

NCBI Summary:The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was identified in error as interleukin 25. This activity has not been reproducible, however, and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
UniProt Code:Q9CPT4
NCBI GenInfo Identifier:61221740
NCBI Gene ID:28106
NCBI Accession:Q9CPT4.1
UniProt Secondary Accession:Q9CPT4,Q3UG74, A2RSI7,
UniProt Related Accession:Q9CPT4
Molecular Weight:17,982 Da
NCBI Full Name:UPF0556 protein C19orf10 homolog
NCBI Synonym Full Names:DNA segment, Chr 17, Wayne State University 104, expressed
NCBI Official Symbol:D17Wsu104e  
NCBI Official Synonym Symbols:Il25; Ly6elg  
NCBI Protein Information:UPF0556 protein C19orf10 homolog
UniProt Protein Name:UPF0556 protein C19orf10 homolog
UniProt Synonym Protein Names:Interleukin-25; IL-25; Stromal cell-derived growth factor SF20
UniProt Gene Name:D17Wsu104e  
UniProt Entry Name:CS010_MOUSE
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