Mouse MANF Recombinant Protein (RPPB0746)

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SKU:
RPPB0746
Product type:
Recombinant Protein
Size:
20ug
Species:
Mouse
Target:
MANF
Synonyms:
Mesencephalic astrocyte-derived neurotrophic factor
Synonyms:
Arginine-rich protein
Synonyms:
Protein ARMET
Synonyms:
Manf
Source:
Escherichia Coli
Uniprot:
Q9CXI5
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Description

Product Name:Mouse MANF Recombinant Protein
Product Code:RPPB0746
Size:20µg
Species:Mouse
Target:MANF
Synonyms:Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET, Manf, Armet.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized MANF in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized MANF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MANF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIEEELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDNQ IDLSTVDLKK LRVKELKKIL DDWGEMCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
Biological Activity:The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 10µg/ml, corresponding to a specific activity of >100 IU/mg.

MANF is a 20kDa protein which belongs to the ARMET family. MANF was originally known as an arginine-rich region protein which was extremely mutated in a large number of tumors. MANF Expression is induced during ER stress, signifying that MANF takes part in protein quality control during ER stress.

MANF Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 158 amino acids and having a molecular mass of 18.2kDa.

UniProt Protein Function:Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9CXI5
NCBI GenInfo Identifier:23396453
NCBI Gene ID:
NCBI Accession:Q9CXI5.1
UniProt Secondary Accession:Q9CXI5
UniProt Related Accession:Q9CXI5
Molecular Weight:20,374 Da
NCBI Full Name:Mesencephalic astrocyte-derived neurotrophic factor
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Mesencephalic astrocyte-derived neurotrophic factor
UniProt Synonym Protein Names:Arginine-rich protein; Protein ARMET
Protein Family:Mannan endo-1,4-beta-mannosidase
UniProt Gene Name:Manf  
UniProt Entry Name:
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