Mouse LYPLA1 Recombinant Protein (RPPB1918)

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SKU:
RPPB1918
Product type:
Recombinant Protein
Size:
25ug
Species:
Mouse
Target:
LYPLA1
Synonyms:
Acyl-protein thioesterase 1
Synonyms:
LYPLA1
Synonyms:
APT-1
Synonyms:
LPL1
Source:
Escherichia Coli
Uniprot:
P97823
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Description

Product Name:Mouse LYPLA1 Recombinant Protein
Product Code:RPPB1918
Size:25µg
Species:Mouse
Target:LYPLA1
Synonyms:Acyl-protein thioesterase 1, LYPLA1, APT-1, LPL1, LYSOPLA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The LYPLA1 protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0)0.1M NaCl,1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MCGNNMSAPM PAVVPAARKA TAAVIFLHGL GDTGHGWAEA FAGIKSPHIK YICPHAPVMP VTLNMNMAMP SWFDIVGLSP DSQEDESGIK QAAETVKALI DQEVKNGIPS NRIILGGFSQ GGALSLYTAL TTQQKLAGVT ALSCWLPLRA SFSQGPINSA NRDISVLQCH GDCDPLVPLM FGSLTVERLK ALINPANVTF KIYEGMMHSS CQQEMMDVKH FIDKLLPPID

LYPLA1 is lysophospholipase which performs on biological membranes to regulate the multifunctional lysophospholipids. LYPLA1 protein hydrolyzes fatty acids from S-acylated cysteine residues in proteins like trimeric G alpha proteins or HRAS and in addition has depalmitoylating activity.

LYPLA1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 250 amino acids (1-230a.a.) and having a molecular mass of 26.8kDa.LYPLA1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LYPLA1: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity. Belongs to the AB hydrolase 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.2.-; Lipid Metabolism - glycerophospholipid; Mitochondrial; PhospholipaseChromosomal Location of Human Ortholog: 1|1 A1Cellular Component: cytosol; mitochondrionMolecular Function: lipase activity; lysophospholipase activity; palmitoyl-(protein) hydrolase activityBiological Process: negative regulation of Golgi to plasma membrane protein transport; protein depalmitoylation
UniProt Protein Details:
NCBI Summary:
UniProt Code:P97823
NCBI GenInfo Identifier:6678760
NCBI Gene ID:18777
NCBI Accession:NP_032892.1
UniProt Secondary Accession:P97823,Q3TJZ0, Q7TPX1, Q8BWM6
UniProt Related Accession:P97823
Molecular Weight:52.1kD
NCBI Full Name:acyl-protein thioesterase 1
NCBI Synonym Full Names:lysophospholipase 1
NCBI Official Symbol:Lypla1  
NCBI Official Synonym Symbols:Pla1a  
NCBI Protein Information:acyl-protein thioesterase 1
UniProt Protein Name:Acyl-protein thioesterase 1
UniProt Synonym Protein Names:Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I
Protein Family:Acyl-protein thioesterase
UniProt Gene Name:Lypla1  
UniProt Entry Name:
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