Mouse IL17A Recombinant Protein (RPPB0609)
- SKU:
- RPPB0609
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Mouse
- Target:
- IL17A
- Synonyms:
- IL17A
- Ctla-8
- Ctla8
- IL-17
- Source:
- Sf9 Insect cells
- Uniprot:
- Q62386
Description
| Product Name: | Mouse IL17A Recombinant Protein |
| Product Code: | RPPB0609 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL17A |
| Synonyms: | IL17A, Ctla-8, Ctla8, IL-17, IL-17A, Il17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The IL17A solution (0.5mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAALEHHHHH H |
Interleukin-17A or IL17A is a cytokine, that has a crucial part in chronic & anti-microbial inflammation. Mouse, rat and human share approximately 60% resemblance is the amino acid sequence. IL17A enhances mucosal & epidermal inflammation when an infection from bacteria occurs, it causes production of chemokines, influx of neutrophils & antibacterial proteins production.
IL17A Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 141 amino acids (26-158 a.a) and having a molecular mass of 16kDa.IL17A is fused to an 8 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane Molecular Function:cytokine activity Biological Process: positive regulation of osteoclast differentiation; positive regulation of interleukin-23 production; positive regulation of transcription from RNA polymerase II promoter; inflammatory response |
| UniProt Code: | Q62386 |
| NCBI GenInfo Identifier: | 2498482 |
| NCBI Gene ID: | 16171 |
| NCBI Accession: | Q62386.1 |
| UniProt Secondary Accession: | Q62386,Q60971, |
| UniProt Related Accession: | Q62386 |
| Molecular Weight: | 17,490 Da |
| NCBI Full Name: | Interleukin-17A |
| NCBI Synonym Full Names: | interleukin 17A |
| NCBI Official Symbol: | Il17a |
| NCBI Official Synonym Symbols: | Il17; Ctla8; IL-17; Ctla-8; IL-17A |
| NCBI Protein Information: | interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8 |
| UniProt Protein Name: | Interleukin-17A |
| UniProt Synonym Protein Names: | Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il17a |
| UniProt Entry Name: | IL17_MOUSE |
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