Mouse IL 7 Recombinant Protein (RPPB0543)
- SKU:
- RPPB0543
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Mouse
- Target:
- IL 7
- Synonyms:
- Lymphopoietin 1 (LP-1)
- pre-B cell factor
- IL-7
- Source:
- Escherichia Coli
- Uniprot:
- P10168
Description
| Product Name: | Mouse IL 7 Recombinant Protein |
| Product Code: | RPPB0543 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL 7 |
| Synonyms: | Lymphopoietin 1 (LP-1), pre-B cell factor, IL-7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Filtered (0.2µm) and lyophilized from a concentrated (1mg/ml) solution in 1×PBS, pH7.4 and 2% trehalose. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin 7 in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL7 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 96.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | ECHIKDKEGK AYESVLMISI DELDKMTGTD SNCPNNEPNF FRKHVCDDTK EAAFLNRAAR KLKQFLKMNI SEEFNVHLLT VSQGTQTLVN CTSKEEKNVK EQKKNDACFL KRLLREIKTC WNKILKGSI |
| Biological Activity: | The ED50was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is less than 0.2 ng/ml, corresponding to a specific activity of >5.0×106 IU/mg. |
Interleukin-7 is a potent lymphoid cell growth factor produced primarily by stromal cells. IL-7 has been shown to support the proliferation and differentiation of pre B- and early T cells as well as displaying a biological effect on cells of NK and myeloid lineages.
Interleukin-7 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 129 amino acids and having a molecular mass of 14.9kDa.
| UniProt Protein Function: | IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Cytokine; Apoptosis; Secreted, signal peptide; Secreted; Cell cycle regulation Cellular Component: extracellular space; extracellular region Molecular Function:interleukin-7 receptor binding; growth factor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity Biological Process: T cell lineage commitment; organ morphogenesis; cell-cell signaling; positive regulation of T cell differentiation; homeostasis of number of cells within a tissue; regulation of gene expression; negative regulation of catalytic activity; positive regulation of B cell proliferation; immune response; positive regulation of organ growth; humoral immune response; bone resorption |
| NCBI Summary: | The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] |
| UniProt Code: | P10168 |
| NCBI GenInfo Identifier: | 124355 |
| NCBI Gene ID: | 16196 |
| NCBI Accession: | P10168.1 |
| UniProt Related Accession: | P10168 |
| Molecular Weight: | 17,727 Da |
| NCBI Full Name: | Interleukin-7 |
| NCBI Synonym Full Names: | interleukin 7 |
| NCBI Official Symbol: | Il7 |
| NCBI Official Synonym Symbols: | Il-7; hlb368; A630026I06Rik |
| NCBI Protein Information: | interleukin-7 |
| UniProt Protein Name: | Interleukin-7 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il7 |
| UniProt Entry Name: | IL7_MOUSE |
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