Mouse IL 7 Recombinant Protein (RPPB0543)

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SKU:
RPPB0543
Product type:
Recombinant Protein
Size:
10ug
Species:
Mouse
Target:
IL 7
Synonyms:
Lymphopoietin 1 (LP-1)
Synonyms:
pre-B cell factor
Synonyms:
IL-7
Source:
Escherichia Coli
Uniprot:
P10168
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Description

Product Name:Mouse IL 7 Recombinant Protein
Product Code:RPPB0543
Size:10µg
Species:Mouse
Target:IL 7
Synonyms:Lymphopoietin 1 (LP-1), pre-B cell factor, IL-7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Filtered (0.2µm) and lyophilized from a concentrated (1mg/ml) solution in 1×PBS, pH7.4 and 2% trehalose.
Solubility:It is recommended to reconstitute the lyophilized Interleukin 7 in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Interleukin-7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL7 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 96.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:ECHIKDKEGK AYESVLMISI DELDKMTGTD SNCPNNEPNF FRKHVCDDTK EAAFLNRAAR KLKQFLKMNI SEEFNVHLLT VSQGTQTLVN CTSKEEKNVK EQKKNDACFL KRLLREIKTC WNKILKGSI
Biological Activity:The ED50was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is less than 0.2 ng/ml, corresponding to a specific activity of >5.0×106 IU/mg.

Interleukin-7 is a potent lymphoid cell growth factor produced primarily by stromal cells. IL-7 has been shown to support the proliferation and differentiation of pre B- and early T cells as well as displaying a biological effect on cells of NK and myeloid lineages.

Interleukin-7 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 129 amino acids and having a molecular mass of 14.9kDa.

UniProt Protein Function:IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell development/differentiation; Cytokine; Apoptosis; Secreted, signal peptide; Secreted; Cell cycle regulation

Cellular Component: extracellular space; extracellular region

Molecular Function:interleukin-7 receptor binding; growth factor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity

Biological Process: T cell lineage commitment; organ morphogenesis; cell-cell signaling; positive regulation of T cell differentiation; homeostasis of number of cells within a tissue; regulation of gene expression; negative regulation of catalytic activity; positive regulation of B cell proliferation; immune response; positive regulation of organ growth; humoral immune response; bone resorption

NCBI Summary:The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
UniProt Code:P10168
NCBI GenInfo Identifier:124355
NCBI Gene ID:16196
NCBI Accession:P10168.1
UniProt Related Accession:P10168
Molecular Weight:17,727 Da
NCBI Full Name:Interleukin-7
NCBI Synonym Full Names:interleukin 7
NCBI Official Symbol:Il7  
NCBI Official Synonym Symbols:Il-7; hlb368; A630026I06Rik  
NCBI Protein Information:interleukin-7
UniProt Protein Name:Interleukin-7
Protein Family:Interleukin
UniProt Gene Name:Il7  
UniProt Entry Name:IL7_MOUSE
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