FITC Anti-Mouse IL-17A Antibody [TC11-18H10.1] (AGEL2035)

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SKU:
AGEL2035
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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FITC Anti-Mouse IL-17A Antibody [TC11-18H10.1]

The Mouse IL-17A Monoclonal Antibody (FITC-conjugated, TC11-18H10-1) is a cutting-edge research tool designed for scientists investigating the role of IL-17A in immune responses and inflammatory processes in mice. This monoclonal antibody, specifically targeting IL-17A, a key pro-inflammatory cytokine, has been validated for use in flow cytometry applications. By binding specifically to IL-17A, this antibody allows for precise detection and analysis of IL-17A-producing cells in various experimental settings.IL-17A is a potent mediator of inflammation and plays a crucial role in the pathogenesis of autoimmune diseases, inflammatory disorders, and host defense against pathogens.

Understanding the function and regulation of IL-17A is essential for developing targeted therapies for conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel diseases. This FITC-conjugated monoclonal antibody provides researchers with a powerful tool to delve deeper into the mechanisms underlying IL-17A-mediated immune responses in mouse models, offering valuable insights for therapeutic development and immunological studies.

Product Title:FITC Anti-Mouse IL-17A Antibody [TC11-18H10.1]
SKU:AGEL2035
Size:50 Tests, 100 Tests, 200 Tests
Clone No:TC11-18H10.1
Synonyms:Interleukin-17A;IL-17;IL-17A;Cytotoxic T-lymphocyte-associated antigen 8;CTLA-8;CTLA8;
Host Species:Rat
Reactivity:Mouse
Application:ICFCM
Isotype:Rat IgG1, κ
Isotype Control:FITC Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q62386
Gene ID:16171
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

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