APC Anti-Mouse IL-17A Antibody [TC11-18H10.1] (AGEL2040)

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SKU:
AGEL2040
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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APC Anti-Mouse IL-17A Antibody [TC11-18H10.1]

The Mouse IL-17A Monoclonal Antibody (APC Conjugated, TC11-18H10-1) is a valuable tool for researchers studying immune responses and inflammatory processes in mouse models. This antibody is specifically designed to target IL-17A, a cytokine involved in the regulation of immune responses and the promotion of inflammation.IL-17A is a key mediator of various autoimmune and inflammatory diseases, making it an important target for research in fields such as immunology, rheumatology, and infectious diseases. By utilizing this monoclonal antibody, researchers can accurately detect and quantify IL-17A in mouse samples using flow cytometry or other assays that rely on APC conjugation.

The TC11-18H10-1 antibody offers high specificity and sensitivity, ensuring reliable results in experimental settings. Its ability to target IL-17A enables researchers to gain valuable insights into the role of this cytokine in different disease pathways and immune processes. Whether investigating the pathogenesis of autoimmune diseases or evaluating therapeutic interventions, this antibody provides a precise and effective means of studying IL-17A biology in mouse models.

Product Title:APC Anti-Mouse IL-17A Antibody [TC11-18H10.1]
SKU:AGEL2040
Size:25µg, 100µg
Clone No:TC11-18H10.1
Synonyms:Interleukin-17A;IL-17;IL-17A;Cytotoxic T-lymphocyte-associated antigen 8;CTLA-8;CTLA8;
Host Species:Rat
Reactivity:Mouse
Application:ICFCM
Isotype:Rat IgG1, κ
Isotype Control:APC Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62386
Gene ID:16171
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

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