APC Anti-Mouse IL-17A Antibody [TC11-18H10.1] (AGEL2037)

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SKU:
AGEL2037
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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APC Anti-Mouse IL-17A Antibody [TC11-18H10.1]

The Mouse IL-17A Monoclonal Antibody (APC Conjugated, TC11-18H10.1) - AGEL2037 is a potent tool for researchers studying interleukin-17A (IL-17A), a cytokine involved in inflammatory responses and immune regulation. This antibody, developed specifically for use in flow cytometry applications, is conjugated to allophycocyanin (APC), allowing for sensitive and specific detection of IL-17A in mouse samples.IL-17A is a key player in the immune response, promoting inflammation and defense against pathogens. Dysregulation of IL-17A signaling has been implicated in various autoimmune diseases, such as psoriasis and rheumatoid arthritis, making it a prime target for therapeutic intervention.

The ability to accurately detect and quantify IL-17A levels in biological samples is essential for understanding its role in disease pathogenesis and for developing targeted treatments.With its high specificity and sensitivity, the Mouse IL-17A Monoclonal Antibody (APC Conjugated, TC11-18H10.1) - AGEL2037 is an invaluable resource for researchers exploring the functions of IL-17A in immune responses, inflammation, and autoimmune disorders. Its precise targeting and reliable performance make it a versatile tool for in-depth investigations into the intricate mechanisms of cytokine-mediated immune modulation.

Product Title:APC Anti-Mouse IL-17A Antibody [TC11-18H10.1]
SKU:AGEL2037
Size:50 Tests, 100 Tests, 200 Tests
Clone No:TC11-18H10.1
Synonyms:Interleukin-17A;IL-17;IL-17A;Cytotoxic T-lymphocyte-associated antigen 8;CTLA-8;CTLA8;
Host Species:Rat
Reactivity:Mouse
Application:ICFCM
Isotype:Rat IgG1, κ
Isotype Control:APC Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q62386
Gene ID:16171
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

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