Mouse IL 16 Recombinant Protein (RPPB0594)

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SKU:
RPPB0594
Product type:
Recombinant Protein
Size:
10ug
Species:
Mouse
Target:
IL 16
Synonyms:
LCF
Synonyms:
Lymphocyte Chemoattractant Factor
Synonyms:
prIL-16
Synonyms:
KIAA4048
Source:
Escherichia Coli
Uniprot:
O54824
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Description

Product Name:Mouse IL 16 Recombinant Protein
Product Code:RPPB0594
Size:10µg
Species:Mouse
Target:IL 16
Synonyms:LCF, Lymphocyte Chemoattractant Factor, prIL-16, KIAA4048, mKIAA4048, Il16, IL-16, Interleukin-16.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Murine IL-16 was lyophilized from 1mg/ml solution after extensive dialysis against 10mM sodium phosphate buffer, pH-7.5.
Solubility:It is recommended to reconstitute the lyophilized Murine IL16 in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Mouse IL-16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution mouse IL16 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 90.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis SDS-PAGE.
Amino Acid Sequence:MHDLNSSTDS AASASAASDI SVESKEATVC TVTLEKTSAG LGFSLEGGKG SLHGDKPLTI NRIFKGDRTG EMVQPGDEIL QLAGTAVQGL TRFEAWNVIK ALPDGPVTIV IRRTSLQCKQ TTASADS

IL-16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of IL-16 is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. IL-16 functions exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two transcript variants encoding different isoforms have been found for this gene.IL-16 stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. Also induces t-lymphocyte expression of interleukin 2 receptor. ligand for cd4.

Interleukin-16 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 127 amino acids and having a molecular mass of 13.2 kDa. The Mouse IL-16 is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL16: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. 3 isoforms of the human protein are produced by alternative promoter.
UniProt Protein Details:

Protein type:Cytokine; DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7 D3|7 47.43 cM

Cellular Component: cytoplasm; intracellular; nucleus; plasma membrane

Molecular Function:cytokine activity; protein binding

Biological Process: induction of positive chemotaxis; leukocyte chemotaxis

UniProt Code:O54824
NCBI GenInfo Identifier:52138550
NCBI Gene ID:16170
NCBI Accession:NP_034681.2
UniProt Secondary Accession:O54824,O70236, Q3TEM4, Q5DTR5, Q8R0G5, Q9QZP6,
UniProt Related Accession:O54824
Molecular Weight:66,471 Da
NCBI Full Name:pro-interleukin-16
NCBI Synonym Full Names:interleukin 16
NCBI Official Symbol:Il16  
NCBI Official Synonym Symbols:mKIAA4048  
NCBI Protein Information:pro-interleukin-16
UniProt Protein Name:Pro-interleukin-16
UniProt Synonym Protein Names:Interleukin-16; IL-16
Protein Family:Pro-interleukin
UniProt Gene Name:Il16  
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