Mouse IL 11 Recombinant Protein (RPPB0562)

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SKU:
RPPB0562
Product type:
Recombinant Protein
Size:
10ug
Species:
Mouse
Target:
IL 11
Synonyms:
AGIF
Synonyms:
Adipogenesis inhibitory factor
Synonyms:
IL-11
Synonyms:
Interleukin-11
Source:
Escherichia Coli
Uniprot:
P47873
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Description

Product Name:Mouse IL 11 Recombinant Protein
Product Code:RPPB0562
Size:10µg
Species:Mouse
Target:IL 11
Synonyms:AGIF, Adipogenesis inhibitory factor, IL-11, Interleukin-11, Il11.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein was lyophilized from a 0.2µm filtered concentrated (1mg/ml) solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized Interleukin 11 in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Interleukin-11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL11 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Biological Activity:The ED50 as determined by the dose-dependant stimulation of the proliferation of murine T11 was found to be less than 2.0 ng/ml, corresponding to a specific activity of 500,000IU/mg.

IL11 is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). IL-11 is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.

Interleukin-11 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19.1kDa. The Mouse IL-11 is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL11: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Belongs to the IL-6 superfamily.
UniProt Protein Details:

Protein type:Cytokine; Cell cycle regulation; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function:growth factor activity; cytokine activity; interleukin-11 receptor binding

Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; negative regulation of hormone secretion; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation

UniProt Code:P47873
NCBI GenInfo Identifier:1352447
NCBI Gene ID:16156
NCBI Accession:P47873.1
UniProt Related Accession:P47873
Molecular Weight:21,522 Da
NCBI Full Name:Interleukin-11
NCBI Synonym Full Names:interleukin 11
NCBI Official Symbol:Il11  
NCBI Official Synonym Symbols:IL-11  
NCBI Protein Information:interleukin-11
UniProt Protein Name:Interleukin-11
UniProt Gene Name:Il11  
UniProt Entry Name:IL11_MOUSE
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