PE Anti-Mouse IL-10 Antibody [JES5-16E3] (AGEL2031)

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SKU:
AGEL2031
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE Anti-Mouse IL-10 Antibody [JES5-16E3]

The Mouse IL-10 Monoclonal Antibody (PE Conjugated) JES5-16E3 (AGEL2031) is a powerful tool for researchers studying the immunoregulatory cytokine IL-10 in mouse models. This monoclonal antibody, conjugated with the fluorescent dye PE, specifically targets IL-10, a key player in immune regulation and anti-inflammatory responses.IL-10 is known for its pivotal role in dampening excessive immune responses and maintaining immune tolerance. The JES5-16E3 antibody provides reliable detection and quantification of IL-10 in samples from mouse models, enabling detailed analysis of its expression and function in various cell types and tissues.

Researchers in immunology, inflammation, and autoimmune disease fields can leverage the specificity and sensitivity of this antibody to delve into the intricate mechanisms of IL-10-mediated immune modulation. With its validated performance in assays like flow cytometry and fluorescence microscopy, the JES5-16E3 antibody is a valuable asset for elucidating the impact of IL-10 in disease pathogenesis and potential therapeutic interventions.

Product Title:PE Anti-Mouse IL-10 Antibody [JES5-16E3]
SKU:AGEL2031
Size:25µg, 100µg
Clone No:JES5-16E3
Synonyms:Interleukin-10;IL-10;Cytokine synthesis inhibitory factor;CSIF;
Host Species:Rat
Reactivity:Mouse
Application:ICFCM
Isotype:Rat IgG2b, κ
Isotype Control:PE Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P18893
Gene ID:16153
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:L-10 was originally described as Cytokine Synthesis Inhibitory Factor (CSIF) by virtue of its ability to inhibit cytokine production by Th1 clones. IL-10 shares over 80% sequence homology with the Epstein-Barr virus protein BCRFI. IL-10 inhibits IFN-γ, TNF-β, and IL-2 production by Th1 clones; inhibits macrophage-mediated IL-1, IL-6, and TNF-α synthesis; suppresses the delayed type hypersensitivity response; stimulates Th2 cell response (which results in elevated antibody production); and promotes mast cell proliferation in combination with IL-4.

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