Mouse IL 1 alpha Recombinant Protein (RPPB0448)

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SKU:
RPPB0448
Product type:
Recombinant Protein
Size:
20ug
Species:
Mouse
Target:
IL 1 alpha
Synonyms:
Interleukin-1 alpha
Synonyms:
IL-1 alpha
Synonyms:
Il1a
Source:
Escherichia Coli
Uniprot:
P01582
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Description

Product Name:Mouse IL 1 alpha Recombinant Protein
Product Code:RPPB0448
Size:20µg
Species:Mouse
Target:IL 1 alpha
Synonyms:Interleukin-1 alpha, IL-1 alpha, Il1a.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:IL 1 alpha protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSSAPYTYQ SDLRYKLMKL VRQKFVMNDS LNQTIYQDVD KHYLSTTWLN DLQQEVKFDM YAYSSGGDDS KYPVTLKISD SQLFVSAQGE DQPVLLKELP ETPKLITGSE TDLIFFWKSI NSKNYFTSAA YPELFIATKE QSRVHLARGL PSMTDFQIS

Interleukin-1 alpha is a proinflammatory cytokine produced by a wide variety of cell types, including macrophages, osteoblasts, monocytes and hepatocytes. Circulating levels of are normally low and only rise after stimulation by agents such as those produced byinflammation, infection or microbial endotoxins. IL-1 alpha possesses a wide variety of biological activities and exerts its effects by binding to specific cell surface receptors. 

IL 1 alpha Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.4kDa.IL 1 alpha is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IL1A: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytokine

Cellular Component: extracellular space; cell surface; plasma membrane; extracellular region; cytosol

Molecular Function:interleukin-1 receptor binding; copper ion binding; cytokine activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; positive regulation of interleukin-2 biosynthetic process; cytokine and chemokine mediated signaling pathway; germ cell programmed cell death; positive regulation of JNK cascade; positive regulation of interleukin-6 production; fever; positive regulation of stress-activated MAPK cascade; negative regulation of cell proliferation; positive regulation of angiogenesis; connective tissue replacement during inflammatory response; response to copper ion; positive regulation of cell division; keratinization; positive regulation of prostaglandin secretion; immune response; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; inflammatory response; positive regulation of cytokine secretion

UniProt Code:P01582
NCBI GenInfo Identifier:124298
NCBI Gene ID:16175
NCBI Accession:P01582.1
UniProt Related Accession:P01582
Molecular Weight:31,023 Da
NCBI Full Name:Interleukin-1 alpha
NCBI Synonym Full Names:interleukin 1 alpha
NCBI Official Symbol:Il1a  
NCBI Official Synonym Symbols:Il-1a  
NCBI Protein Information:interleukin-1 alpha; IL-1 alpha
UniProt Protein Name:Interleukin-1 alpha
Protein Family:Interleukin
UniProt Gene Name:Il1a  
UniProt Entry Name:IL1A_MOUSE
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