Purified Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114] (AGEL0018)

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SKU:
AGEL0018
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2b
Clone:
M5/114
Conjugation:
Unconjugated
Applications:
FC
IHC
IP
Frequently bought together:

Description

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Purified Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114]

The I-A/I-E Mouse Monoclonal Antibody (M5/114) is designed for research involving I-A/I-E, critical molecules within the Major Histocompatibility Complex (MHC) class II system. These molecules are key to the immune system's ability to present antigens and initiate immune responses. This monoclonal antibody, produced in mice, is highly reactive with mouse I-A/I-E and is validated for use in flow cytometry applications. It binds specifically to I-A/I-E proteins, enabling accurate detection and analysis in various cell types, making it ideal for studies in immunology and infectious disease research.I-A/I-E molecules are fundamental for the adaptive immune response, playing a central role in antigen presentation to CD4+ T cells. Their significance in immune regulation makes them valuable targets for research into diseases such as autoimmune disorders, chronic inflammatory conditions, and infectious diseases.

The Mouse I-A/I-E Monoclonal Antibody (M5/114) is essential for researchers aiming to understand the mechanisms of antigen presentation and develop therapies that modulate immune function.By providing precise and reliable detection of I-A/I-E molecules, this antibody supports detailed studies of immune response pathways, contributing to the advancement of therapeutic strategies for autoimmune diseases and other immune-related conditions. Understanding the activity of I-A/I-E is crucial for the development of novel immunotherapies that harness or modulate antigen presentation in these contexts.

Product Title:Purified Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114]
SKU:AGEL0018
Size:25µg, 100µg
Clone No:M5/114
Synonyms:H2-Ab1/Eb1;Major histocompatibility protein class II beta chain;MHC class II H2-IA-beta-psi;I-E beta MHC class II;MHC class II;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Purified Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P14483 O78196
Gene ID:14961,14969
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:These class II molecules are expressed on antigen presenting cells (including B cells) and a subset of T cells from H-2b,d,q,r bearing mice and are involved in antigen presentation to T cells expressing CD3/TCR and CD4 proteins.

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