Biotin Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114] (AGEL0019)

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SKU:
AGEL0019
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2b
Clone:
M5/114
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114]

The Biotin-Conjugated Mouse I-A/I-E Monoclonal Antibody (M5/114) is designed for advanced research involving I-A/I-E, critical molecules of the Major Histocompatibility Complex (MHC) class II system. These molecules are essential for the immune system's antigen presentation and subsequent activation of immune responses. This monoclonal antibody, produced in mice, is highly reactive with mouse I-A/I-E and is validated for use in flow cytometry and immunohistochemistry applications. The biotin conjugation enhances the antibody's utility in various biotin-avidin/streptavidin-based assay systems, enabling precise detection and analysis in multiple cell types.I-A/I-E molecules are fundamental to the adaptive immune response, playing central roles in presenting antigens to CD4+ T cells. Their critical function in immune regulation makes them valuable targets for research into autoimmune diseases, chronic inflammatory conditions, and infectious diseases.

The Biotin-Conjugated Mouse I-A/I-E Monoclonal Antibody (M5/114) is a vital tool for researchers aiming to elucidate the mechanisms of antigen presentation and develop therapies that modulate immune function.By facilitating accurate and reliable detection of I-A/I-E molecules, this antibody supports detailed studies of immune response pathways, contributing to the advancement of therapeutic strategies for autoimmune diseases and other immune-related conditions. Understanding the activity of I-A/I-E is crucial for the development of novel immunotherapies that harness or modulate antigen presentation in various disease contexts.

Product Title:Biotin Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114]
SKU:AGEL0019
Size:25µg, 100µg
Clone No:M5/114
Synonyms:H2-Ab1/Eb1;Major histocompatibility protein class II beta chain;MHC class II H2-IA-beta-psi;I-E beta MHC class II;MHC class II;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Biotin Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P14483 O78196
Gene ID:14961,14969
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:These class II molecules are expressed on antigen presenting cells (including B cells) and a subset of T cells from H-2b,d,q,r bearing mice and are involved in antigen presentation to T cells expressing CD3/TCR and CD4 proteins.

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