PE/Cyanine7 Anti-Human/Mouse CD44 Antibody [IM7] (AGEL1285)

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SKU:
AGEL1285
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine7 Anti-Human/Mouse CD44 Antibody [IM7]

The Mouse/Human CD44 Monoclonal Antibody PE-Cyanine7 Conjugated (IM7-AGEL1285) is a specialized antibody designed for research applications involving the CD44 protein, a cell surface glycoprotein that plays a key role in cell adhesion and migration. With a PE-Cyanine7 conjugation, this antibody offers reliable detection and analysis in flow cytometry and immunofluorescence techniques.CD44 is a versatile protein involved in various cellular processes, including cell-cell interactions, cell signaling, and lymphocyte homing. Its expression patterns have been associated with disease progression in cancer and other pathologies, making it a valuable target for investigating disease mechanisms and developing potential therapeutic interventions.

This antibody specifically recognizes both mouse and human CD44 variants, enabling cross-species research studies with high sensitivity and specificity. Its conjugation with PE-Cyanine7 allows for multi-color flow cytometry experiments, facilitating the precise identification and characterization of CD44-expressing cell populations. Researchers in immunology, oncology, and cell biology can benefit from the use of this antibody to uncover new insights into the functions of CD44 and its implications in health and disease.

Product Title:PE/Cyanine7 Anti-Human/Mouse CD44 Antibody [IM7]
SKU:AGEL1285
Size:25µg, 100µg
Clone No:IM7
Synonyms:CD44 antigen;CD44;CDw44;Epican;Phagocytic glycoprotein 1;PGP-1;Phagocytic glycoprotein I;PGP-I;CD44;LHR; MDU2; MDU3; MIC4;
Host Species:Rat
Reactivity:Human;Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:PE/Cyanine7 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P15379 P16070
Gene ID:12505,960
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

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