PE/Cyanine7 Anti-Mouse/Human CD11b Antibody [M1/70] (AGEL1109)

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SKU:
AGEL1109
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
M1/70
Conjugation:
PE/Cy7
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse/Human CD11b Antibody [M1/70]

The Mouse and Human CD11b Monoclonal Antibody (PE/Cyanine7 Conjugated) M1/70 (AGEL1109) is a powerful tool for researchers studying immune cells expressing the CD11b molecule. This monoclonal antibody, conjugated with PE and Cyanine7, is specifically designed to target CD11b, a key integrin involved in various immune responses.CD11b, also known as Mac-1, is a cell surface receptor that plays a crucial role in cell adhesion and migration, particularly in the context of inflammation and immune activation. By targeting CD11b, researchers can effectively identify and analyze immune cell populations, such as macrophages, dendritic cells, and neutrophils, in both mouse and human samples.The PE/Cyanine7 conjugation of this antibody allows for easy detection and quantification of CD11b-expressing cells using flow cytometry.

This enables researchers to study the dynamics of immune cell populations in different tissues and disease states, providing valuable insights into the immune response mechanisms.The M1/70 monoclonal antibody is highly specific and validated for use in various applications, including flow cytometry, immunofluorescence, and immunohistochemistry. Its versatility and reliability make it an essential tool for studies focusing on immunology, inflammation, and infectious diseases.Overall, the Mouse and Human CD11b Monoclonal Antibody (PE/Cyanine7 Conjugated) M1/70 (AGEL1109) is a valuable asset for researchers interested in dissecting the roles of CD11b-expressing immune cells in health and disease, paving the way for a better understanding of immune system dynamics and potential therapeutic targets.

Product Title:PE/Cyanine7 Anti-Mouse/Human CD11b Antibody [M1/70]
SKU:AGEL1109
Size:25µg, 100µg
Clone No:M1/70
Synonyms:Integrin alpha-M;Itgam;CD11 antigen-like family member B;CR-3 alpha chain;Leukocyte adhesion receptor MO1;CD11b;
Host Species:Rat
Reactivity:Human;Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:PE/Cyanine7 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P05555 P11215
Gene ID:16409,3684
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

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