Purified Anti-Mouse/Human CD11b Antibody [M1/70] (AGEL0304)

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SKU:
AGEL0304
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Host Species:
Rat
Isotype:
IgG2b
Clone:
M1/70
Conjugation:
Unconjugated
Applications:
FC
IP
IHC
Frequently bought together:

Description

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Purified Anti-Mouse/Human CD11b Antibody [M1/70]

The Mouse/Human CD11b Monoclonal Antibody (M1/70) (AGEL0304) is a versatile tool designed for researchers investigating CD11b, a cell surface glycoprotein involved in various immune functions. This monoclonal antibody is specifically engineered for cross-reactivity with both mouse and human samples, allowing for broader applicability in studies across species.With its high specificity and sensitivity, the M1/70 antibody is ideal for a range of experimental applications, including flow cytometry, immunohistochemistry, and immunoprecipitation. By targeting the CD11b protein, researchers can explore its role in processes such as cell adhesion, phagocytosis, and immune response modulation. This antibody enables precise detection and analysis of CD11b expression in different cell types and tissues, facilitating in-depth investigations into immune system functions and related diseases.

The CD11b glycoprotein is a key player in the regulation of inflammatory responses and immune cell activation. Its involvement in various pathological conditions, including autoimmune disorders, infections, and cancer, underscores its significance as a potential therapeutic target. By utilizing the M1/70 antibody to study CD11b, researchers can unravel the complex mechanisms underlying immune dysregulation and develop targeted approaches for intervention in diseases where CD11b dysregulation is implicated.

Product Title:Purified Anti-Mouse/Human CD11b Antibody [M1/70]
SKU:AGEL0304
Size:25µg, 100µg
Clone No:M1/70
Synonyms:Integrin alpha-M;Itgam;CD11 antigen-like family member B;CR-3 alpha chain;Leukocyte adhesion receptor MO1;CD11b;
Host Species:Rat
Reactivity:Human;Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Purified Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P05555 P11215
Gene ID:16409,3684
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

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