The Mouse GR-1 Monoclonal Antibody (Biotin Conjugated, RB6-8C5) is a powerful tool for researchers studying immune cells in mice. This antibody, conjugated with biotin for enhanced detection capabilities, targets the GR-1 antigen commonly found on granulocytes and monocytes. By specifically binding to GR-1, this antibody enables precise identification and analysis of these immune cell populations in various experimental settings.GR-1, also known as Ly-6G/Ly-6C, is a key marker for understanding the role of granulocytes and monocytes in immune responses, inflammation, and various disease states. Studies using the GR-1 antibody can provide valuable insights into the dynamics of these cell populations in research areas such as immunology, infectious diseases, and inflammation.
By accurately detecting and quantifying GR-1-expressing cells, researchers can further elucidate the functions and interactions of these crucial immune cell subsets.Whether investigating immune cell responses in infectious models, studying inflammatory processes, or exploring the impact of immunotherapies, the Mouse GR-1 Monoclonal Antibody offers a reliable tool for precise analysis and characterization. With its biotin conjugation enhancing detection sensitivity, this antibody is a valuable asset for researchers seeking to delve deeper into the intricate workings of immune cell populations in mice.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:
P35461 P0CW03
Gene ID:
546644 ,17067
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
Gr-1 is a 21-25 kD protein also known as Ly-6G/Ly-6C. This myeloid differentiation antigen is a glycosylphosphatidylinositol (GPI)-linked protein expressed on granulocytes and macrophages. In bone marrow, the expression levels of Gr-1 directly correlate with granulocyte differentiation and maturation; Gr-1 is also transiently expressed on bone marrow cells in the monocyte lineage. Immature Myeloid Gr-1+ cells play a role in the development of antitumor immunity.
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