Mouse Flt3 Ligand Recombinant Protein (RPPB0259)
- SKU:
- RPPB0259
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Mouse
- Target:
- Flt3 Ligand
- Synonyms:
- Fms-related tyrosine kinase 3 ligand
- FLK2
- STK1
- CD135
- Source:
- Escherichia Coli
- Uniprot:
- P49772
Description
| Product Name: | Mouse Flt3 Ligand Recombinant Protein |
| Product Code: | RPPB0259 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | Flt3 Ligand |
| Synonyms: | Fms-related tyrosine kinase 3 ligand, FLK2, STK1, CD135, Stem Cell Tyrosine Kinase 1, FLT3LG, Flt3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The FLT3L Mouse protein was lyophilized from sterile filtered solution containing 10mM sodium phosphate, pH 7.5. |
| Solubility: | It is recommended to reconstitute the lyophilized Flt3l Mouse recombinant in sterile 18M?-cm H2O at a concentration of 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Flt3-Ligand although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Flt-3 Ligand should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ DEKHCKALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI HFVTSCTFQP LPECLRFVQT NISHLLKDTC TQLLALKPCI GKACQNFSRC LEVQCQPDSS TLLPPRSPIA LEATELPEPR PRQ |
| Biological Activity: | The ED50, calculated by the dose-dependent proliferation of mouse AML5 cells is 1.66ng/ml, corresponding to a specific activity of 6.0x105 units/mg. |
FLT3 ligand is a receptor for the fl cytokine has a tyrosine-protein kinase activity & a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand synergizes with other CSFs and interleukins to induce growth and differentiation.
Flt3-Ligand Mouse Recombinant produced in E.Coli is a non-glycosylated, polypeptide chain containing 163 amino acids and having a molecular mass of 18.6kDa. Flt3-Ligand is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Ligand, receptor tyrosine kinase; Cytokine Cellular Component: extracellular space; cell surface; membrane; plasma membrane; extracellular region; integral to membrane Molecular Function:protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding Biological Process: positive regulation of natural killer cell differentiation; regulation of myeloid dendritic cell activation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of myoblast differentiation |
| UniProt Code: | P49772 |
| NCBI GenInfo Identifier: | 1706819 |
| NCBI Gene ID: | 14256 |
| NCBI Accession: | P49772.1 |
| UniProt Secondary Accession: | P49772,Q64085, |
| UniProt Related Accession: | P49772 |
| Molecular Weight: | 28,259 Da |
| NCBI Full Name: | Fms-related tyrosine kinase 3 ligand |
| NCBI Synonym Full Names: | FMS-like tyrosine kinase 3 ligand |
| NCBI Official Symbol: | Flt3l |
| NCBI Official Synonym Symbols: | Ly72L; Flt3lg |
| NCBI Protein Information: | fms-related tyrosine kinase 3 ligand; flt3 ligand |
| UniProt Protein Name: | Fms-related tyrosine kinase 3 ligand |
| UniProt Synonym Protein Names: | SL cytokine |
| Protein Family: | Receptor-type tyrosine-protein kinase |
| UniProt Gene Name: | Flt3lg |
| UniProt Entry Name: | FLT3L_MOUSE |
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