Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. In familial combined hyperlipidemia (FCHL), FABP4 correlated to body mass index (BMI), waist circumference and homeostasis model assessment (HOMA) index.FABP4 levels were associated with triglyceride-rich lipoproteins. In humans serum FABP4 levels correlate significantly with features of PCOS. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index, triglycerides, HDL-cholesterol concentrations and blood pressure. Patients in the highest quartile of FABP4 presented a six-fold increased odds ratio for MS and a three-fold increased odds for LD, adjusted by age, sex, body-mass index and the antiretroviral therapy. FABP4 is a strong plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.
Product Name:
Mouse FABP4/A-FABP Recombinant Protein (RPES0703)
Product Code:
RPES0703
Size:
20µg
Species:
Mouse
Expressed Host:
HEK293 Cells
Synonyms:
422/aP2,ALBP/Ap2,Ap2,Lbpl
Accession:
NP_077717.1
Sequence:
Cys2-Ala132
Fusion tag:
N-His & C-MYC
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the mouse Fabp4 (NP_077717.1) (Cys2-Ala132) was expressed with a polyhistidine tag at the N-terminus and a myc tag at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
16.5 kDa
Formulation:
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 20 % glycerol, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
